Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Yui-Wing Francis Lam, Ph.D.

Lam photo

RESEARCH

Significant variability in efficacy and toxicity of medications among patients is largely attributed to innate differences in their capacity to eliminate and react to medications.  Dr. Lam has studied how ethnicity and genetic differences affect disposition and response to psychotherapeutic drugs.  This has translated to improved understanding of the biological basis for why patients require different doses to elicit appropriate responses, particularly Asians.  Dr. Lam’s earlier findings suggested a genetic basis for variation in drug metabolism and response in Mexican Americans in San Antonio.  His current focus is whether variation in genes that encode enzymes, transporters, and targets in Hispanics can be utilized for personalized cancer therapy, and is working with CTRC investigators to integrate pharmacogenomics into anticancer drug development.

Selected publications

Lam YW. Scientific challenges and implementation barriers to translation of pharmacogenomics in clinical practice. ISRN Pharmacol. 2013;2013:641089.

Lam YW, Ereshefsky L, Port A, Timmer CJ, Dogterom P. Rifampin modulation of the disposition of gepirone and its metabolites. Open Drug Metab J 2009;3:1-7.

Lam YW, Gaedigk A, Ereshefsky L, Alfaro CL, Simpson J. CYP2D6 inhibition by selective serotonin reuptake inhibitors: analysis of achievable steady-state plasma concentrations and the effect of ultrarapid metabolism at CYP2D6. Pharmacotherapy. 2002 Aug;22(8):1001-6.

Lam YW, Jann MW, Chang WH, Yu HS, Lin SK, Chen H, Davis CM. Intra- and interethnic variability in reduced haloperidol to haloperidol ratios. J Clin Pharmacol. 1995 Feb;35(2):128-36.

Lam YW, Chang WH, Jann MW, Chen H. Interindividual variabilities in haloperidol interconversion and the reduced haloperidol/haloperidol ratio. Neuropsychopharmacology. 1992 Aug;7(1):33-9.

Professor
Pharmacology

Education

PharmD, Clinical Pharmacy, University of Minnesota, 1984

Contact

Email: LAMF@UTHSCSA.EDU

Phone: 210-567-8355

Research Profile
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