Aging is the primary
driving force for the development of obesity, type 2 diabetes, cardiovascular, neurodegenerative,
and other aging-related diseases.
However, the underlying molecular mechanisms remain poorly identified.
Dr. Yuguang (Roger) Shi’s lab focuses on translational aspects of aging-related metabolic diseases
using molecular, cellular, metabolic, and transgenic approaches. Our work has
recently identified a critical missing link between mitochondrial dysfunction
in aging and the onset of various aging-related diseases, paving the way for the
development of novel treatment for these pathogenic conditions.
We are also
uncovering novel signaling pathways that regulates glucose-sensing by
pancreatic beta cells, since a loss of glucose responsiveness by pancreatic
beta cell is a major pathological event that triggers the onset of type 2
diabetes. The lab is recruiting graduate students and
P., Liu, X., Zhang, J., and Shi*,
Y. (2015). Cardiolipin Remodeling by Tafazzin
Is Selectively Required for the Initiation of Mitophagy. Autophagy
Liu X, Nie J, Zhang J, Kimball SR, Zhang H, Zhang WJ, Jefferson LS, Cheng Z, Ji
Q, Shi Y.ALCAT1
controls mitochondrial etiology of fatty liver diseases, linking defective
mitophagy to steatosis. Hepatology. 2015 Feb;61(2):486-96.
Liu X, Lilley BN, Zhang H, Pan YA, Kimball SR, Zhang J, Zhang W, Wang L,
Jefferson LS, Sanes JR, Han X, Shi
Y. SAD-A kinase controls islet β-cell size and function as a
mediator of mTORC1 signaling. Proc Natl Acad Sci USA.
2013 Aug 20;110(34):13857-62.
Lilley BN, Pan YA, Faruque O, Liu X, Zhang W, Sanes JR, Han X, Shi Y. SAD-A
potentiates glucose-stimulated insulin secretion as a mediator of glucagon-like
peptide 1 response in pancreatic β cells. Mol Cell Biol. 2013
Li J, Liu
X, Wang H, Zhang W, Chan DC, Shi
Y. Lysocardiolipin acyltransferase 1 (ALCAT1) controls
mitochondrial DNA fidelity and biogenesis through modulation of MFN2
expression. Proc Natl Acad Sci USA. 2012 May 1;109(18):6975-80.
Romestaing C, Han X, Li Y, Hao X, Wu Y, Sun C, Liu X, Jefferson LS, Xiong J,
Lanoue KF, Chang Z, Lynch CJ, Wang H, Shi
Y. Cardiolipin remodeling
by ALCAT1 links oxidative stress and mitochondrial dysfunction to obesity.Cell Metab. 2010 Aug 4;12(2):154-65.
List of Published Work in MyBibliography: