cancer is the most common malignancy among women in the Western world.
Between five to ten percent of breast cancer cases are hereditary, the majority of
which are caused by germline mutations in the breast cancer
susceptibility gene BRCA1 or BRCA2.
In addition, germline mutations in
these two genes also lead to increased risk of hereditary ovarian
The long-term objective of Dr. Yanfen Hu's research is to elucidate the
underlying mechanism by which BRCA1 suppresses development of breast and
ovarian cancers in women.
Parameswaran B, Chiang HC, Lu Y, Coates J, Deng CX, Baer R, Lin HK, Li R, Paull TT, and Hu Y. (2015) Damage-Induced BRCA1 Phosphorylation by Chk2 Contributes to the Timing of End Resection. Cell Cycle 14(3): 437-448
S, Ashcraft K, Jahid MJ, April C, Ghajar CM, Ruan J, Wang H, Foster M,
Hughes DC, Ramirez AG, Huang T, Fan JB, Hu Y, Li R. Regulation of adipose oestrogen output by mechanical stress. Nat Commun. 2013;4:1821.
Lu Y, Li J, Cheng D, Parameswaran B, Zhang S, Jiang Z, Yew PR, Peng J, Ye Q, Hu Y. The F-box protein FBXO44 mediates BRCA1 ubiquitination and degradation. J Biol Chem. 2012 Nov 30;287(49):41014-22.
Lu Y, Amleh A, Sun J, Jin X, McCullough SD, Baer R, Ren D, Li R, Hu Y. Ubiquitination and proteasome-mediated degradation of BRCA1 and BARD1 during steroidogenesis in human ovarian granulosa cells. Mol Endocrinol. 2007 Mar;21(3):651-63.
Hu Y*, Ghosh S, Amleh A, Yue W, Lu Y, Katz A, Li R*. Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression. Oncogene. 2005 Dec 15;24(56):8343-8. (* co-corresponding
Ghosh S, Wu Y, Li R, Hu Y. Jun proteins modulate the ovary-specific promoter of aromatase gene in ovarian granulosa cells via a cAMP-responsive element. Oncogene. 2005 Mar 24;24(13):2236-46.