As a principal scientist in SWRI, Dr. Cheng develops new technology platforms and expands existing capabilities on biomedical material engineering. His areas of research interest include nanomaterial, biomaterial, tissue engineering, nanomedicine and regenerative medicine, and medical device. His research interests emphasize on developing synthetic soft and hard biomaterials (polymer hydrogel, bioceramic, and composites) and natural biomaterials (e.g., collagen, chitosan) for a wide range of applications such as drug/gene/vaccine delivery for prevention or treatment of diseases, wound healing and tissue engineering, bone grafts, and biosensors. He also supports the program and clients by using the experience in cell culture (cancer cells, bone marrow stromal cells, fibroblasts), animal and human subjects tests, and general biomaterial and tissue evaluation and testing.
At SwRI, Dr. Cheng has been a principal investigator/project manager on multiple projects including multifunctional, aligned collagen for tendon/ligament repair; Mg alloy for bone tissue engineering; antimicrobial/biocidal testing of compounds and devices; magnetic calcium phosphate nanoparticles; medical device development; and microencapsulation of drugs/actives and particulate adjuvants for vaccines. He has been a key contributor to several programs including bone-targeting nanoparticles; antimicrobial, anti-abrasion coating on orthopedic implants; haemoglobin encapsulation; collagen-hydroxyapatite perfusion scaffold for mesenchymal stem cell expansion; aligned carbon nanotube-collagen fiber for tendon repair; and carbon nanotube-collagen fiber coupled with neuron progenitor cells (NPCs) for neural regeneration; transdermal delivery, and disinfectant testing. Dr. Cheng is a study director on several regulated projects which require either Good Laboratory Practices (GLP) or FDA-compliant ISO 13485 medical device quality assurance compliance.
Cheng, X. G.; Yoo, J. Y.; Hale, R. G., Biomask for skin regeneration. Regenerative Medicine 2014, 9, (3), 245-
Cheng, X. G.; Yoo, J. Y.; Hale, R. G.; Davis, M. R.; Kang, H. W.; Jee, S. S., 3D printed biomaterials for
maxillofacial tissue engineering and reconstruction – a review Open Journal of Biomedical Materials Research 2014, 1,
Cheng, X. G.; Tsao, C.; Sylvia, V. L.; Cornet, D.; Nicolella, D. P.; Bredbenner, T. L.; Christy, R. J., Plateletderived
growth-factor-releasing aligned collagen–nanoparticle fibers promote the proliferation and tenogenic
differentiation of adipose-derived stem cells. Acta Biomaterialia 2014, 10, (3), 1360-1369.
Poenitzsch, V.; Bredbenner, T. L.; Hornsby, P. J.; Cornell, L.; Cheng, X. G., Electrochemically Directed
Assembly of Carbon Nanotubes (CNTs) and Collagen Macromolecules into Macroscopic Hybrid Fibers. Open Journal of
Advanced Materials Research 2013, 1, (1), 7-12.
Cheng, X. G.; Tsao, C.; Saul, J. M.; Sylvia, V.; Cornet, D.; Christy, R., Comparison of Two Nanoparticle
Formulations for Localized Delivery of Platelet-Derived Growth Factor (PDGF) from Aligned Collagen Fibers
Pharmaceutical Nanotechnology 2013, 1, (1), 1-10.
Cheng, X. G.; Poenitzsch, V.; Cornell, L.; Tsao, C.; Potter, T., Electrochemical Bioencapsulation of
Nanomaterials into Collagen for Biomedical Applications. Journal of Encapsulation and Adsorption Science 2013, 3, 16-
Antebi, B.; Cheng, X. G.; Harris, J.; Gower, L. B.; Cheng, X.; Ling, J., Biomimetic Collagen–Hydroxyapatite
Composite Fabricated Via a Novel Perfusion-Flow Mineralization Technique. Tissue Engineering - Part C: Methods
2013, 19, (7), 1-10.
Montserrat, R.; Patrick, A.; Désirée, W.; Tyler, W.; Gutierrez, G.; Rossini, G.; Desai, S.; Wellinghoff, S.; Yu, H.;
Cheng, X. G., Design and assessment of a wrapped cylindrical Ca-P AZ31 Mg alloy for critical-size ulna defect repair.
Journal of Biomedical Material Research (Part B, Applied Biomaterials) 2012, 100B, 206-216.
Cheng, X. G.; Desai, S., Preparation of Nanoparticle-containing Aligned Collagen Fibers for Dense Connective
Tissue Repair and Regeneration. MRS conference proceedings, Cambridge Journals Online 2012, 1417, 5.
Swanson, T. E.; Cheng, X. G.; Friedrich, C., The Development of Chitosan-vancomycin Antimicrobial Coatings
on Titanium Implants. Journal of Biomedical Materials Research Part A 2011, 97A, (2), 167-176.
Gurkan, U. A.; Cheng, X. G.; Kishore, V.; Uquillas, J. A.; Akkus, O., Comparison of morphology, orientation,
and migration of tendon derived fibroblasts and bone marrow stromal cells on electrochemically aligned collagen
constructs. Journal of Biomedical Materials Research Part A 2010, 94A, (4), 1070-1079.
Diegmueller, J. J.; Cheng, X. G.; Akkus, O., Modulation of Hydroxyapatite Nanocrystal Size and Shape by
Polyelectrolytic Peptides. Crystal Growth & Design 2009, 9, (12), 5220-5226.
Cheng, X. G.; Haggins, D. G.; York, R. H.; Yeni, Y. N.; Akkus, O., Analysis of crystals leading to joint
arthropathies by Raman Spectroscopy: comparision with compensated polarizing imaging. Applied Spectroscopy 2009,
63, (4), 381-6, PMID: 19366502
Dai, L. J.; Cheng, X. G.; Gower, L. B., Transition Bars during Transformation of an Amorphous Calcium
Carbonate Precursor. Chemistry of Materials 2008, 20, (22), 6917-6928.
Cheng, X. G.; Gurkan, U. A.; Dehen, C. J.; Tate, M. P.; Hillhouse, H. W.; Simpson, G. J.; Akkus, O., An
electrochemical fabrication process for the assembly of anisotropically oriented collagen bundles. Biomaterials 2008, 29,
Olszta, M. J.; Cheng, X. G.; Jee, S. S.; Kumar, R.; Kim, Y. Y.; Kaufman, M. J.; Douglas, E. P.; Gower, L. B.,
Bone structure and formation: A new perspective. Materials Science & Engineering R-Reports 2007, 58, (3-5), 77-116.
Cheng, X. G.; Kuhn, L., Chemotherapy drug delivery from calcium phosphate nanoparticles. International
Journal of Nanomedicine 2007, 2, (4), 667-674.
Cheng, X. G.; Varona, P. L.; Olszta, M. J.; Gower, L. B., Biomimetic synthesis of calcite films by a polymerinduced
liquid-precursor (PILP) process 1. Influence and incorporation of magnesium. Journal of Crystal Growth 2007,
307, (2), 395-404.
Cheng, X. G.; Gower, L. B., Molding mineral within microporous hydrogels by a polymer-induced liquidprecursor
(PILP) process. Biotechnology Progress 2006, 22, (1), 141-149.
Cheng, X. G.; Wang, J.; Yuan, M. J.; He, J. S., Preparation of microcellular composites with biomimetic structure
via supercritical fluid technology. Chinese Science Bulletin 2001, 46, (11), 909-911.