The goal of Dr. Xiao-Dong Chen's lab is to reconstitute tissue-specific stem cell niche in vitro to control stem cell fate for
tissue regenerative purposes.
Block TJ, Marinkovic M, Tran ON, Gonzalez AO, Marshall A, Dean DD, Chen XD. Restoring the quantity and quality of elderly human mesenchymal stem cells for autologous cell-based therapies. Stem Cell Res Ther. 2017 Oct 27;8(1):239.
Wu J, Sun Y, Block TJ, Marinkovic M, Zhang ZL, Chen R, Yin Y, Song J, Dean DD, Lu Z, Chen XD. Umbilical cord blood-derived non-hematopoietic stem cells retrieved and expanded on bone marrow-derived extracellular matrix display pluripotent characteristics. Stem Cell Res Ther. 2016 Dec 1;7(1):176.
Marinkovic M, Block TJ, Rakian R, Li Q, Wang E, Reilly MA, Dean DD, Chen XD. One size does not fit all: developing a cell-specific niche for in vitro study of cell behavior. Matrix Biol. 2016 May-Jul;52-54:426-441.
Rakian R, Block TJ, Johnson SM, Marinkovic M, Wu J, Dai Q, Dean DD, Chen XD. Native extracellular matrix preserves mesenchymal stem cell "stemness" and differentiation potential under serum-free culture conditions. Stem Cell Res Ther. 2015 Dec 1;6:235.
Zhang BX, Zhang ZL, Lin AL, Wang H, Pilia M, Ong JL, Dean DD, Chen XD, Yeh CK. Silk fibroin scaffolds promote formation of the ex vivo niche for salivary gland epithelial cell growth, matrix formation, and retention of differentiated function. Tissue Eng Part A. 2015 May;21(9-10):1611-20.