The research in Dr. Thomas Slaga's laboratory is focused on
glucocorticoid hormones (GC), very potent inhibitors of physiological
DNA synthesis in keratinocytes in vivo.
These hormones are also
very effective in preventing carcinogen- and tumor promoter-induced skin
hyperplasia, inflammation, and mouse skin tumor formation when applied
to skin together with a carcinogen or a tumor promoter.
They and others
have shown, however, that the GC do not affect the growth of either
established papillomas, squamous cell carcinomas (SCC), or transformed
keratinocytes in vitro.
In addition, they recently found that the GC do not affect glucocorticoid-responsive genes in transformed keratinocytes both in vitro and in vivo.
Zhang Y, Chang FM, Huang J, Junco JJ, Maffi SK, Pridgen HI, Catano G, Dang H, Ding X, Yang F, Kim DJ, Slaga TJ, He R, Wei SJ. DSSylation,
a novel protein modification targets proteins induced by oxidative
stress, and facilitates their degradation in cells. Protein Cell. 2014 Feb;5(2):124-40.
Kowalczyk P, Junco JJ, Kowalczyk MC, Sosnowska R, Tolstykh O, Walaszek Z, Hanausek M, Slaga TJ. The effects of dissociated glucocorticoids RU24858 and RU24782 on TPA-induced skin tumor promotion biomarkers in SENCAR mice. Mol Carcinog. 2013 Jul 12.
Kowalczyk MC, Junco JJ, Kowalczyk P, Tolstykh O, Hanausek M, Slaga TJ, Walaszek Z. Effects of combined phytochemicals on skin tumorigenesis in SENCAR mice. Int J Oncol. 2013 Sep;43(3):911-8.
Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD,
Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety assessment of diethanolamides as used in cosmetics. Int J Toxicol. 2013 May-Jun;32(3 Suppl):36S-58S.
Junco JJ, Mancha A, Malik G, Wei SJ, Kim DJ, Liang H, Slaga TJ. Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. Mol Cancer Res. 2013 Dec;11(12):1521-9.