Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Susan L. Mooberry, Ph.D.

Moobeerry photo2

RESEARCH

Our research is focused on identifying new drugs for the treatment of cancer and understanding the molecular mechanism of known drugs to improve their use.  Our laboratory has expertise natural products drug discovery.  Many of the most useful drugs used to treat cancer target microtubules. We have discovered many new microtubule targeting agents from nature and in collaboration with synthetic chemists.  Interrupting the functions of microtubules is detrimental to cells and particularly to abnormal “unbalanced” cancer cells, thus leading to anticancer effects.  The identification of new microtubule disrupting agents that can overcome drug resistance that limits the efficacy of our current anticancer drugs is one of our goals as is understanding how these drugs cause anticancer effects. 


Selected Publications

Rohena CC, Mooberry SL. Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities. Nat Prod Rep. 2014 Feb 11;31(3):335-55.

Du L, Robles AJ, King JB, Powell DR, Miller AN, Mooberry SL, Cichewicz RH. Crowdsourcing natural products discovery to access uncharted dimensions of fungal metabolite diversity. Angew Chem Int Ed Engl. 2014 Jan 13;53(3):804-9.

Risinger AL, Li J, Bennett MJ, Rohena CC, Peng J, Schriemer DC, Mooberry SL. Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity. Cancer Res. 2013 Nov 15;73(22):6780-92.

Rohena CC, Peng J, Johnson TA, Crews P, Mooberry SL. Chemically diverse microtubule stabilizing agents initiate distinct mitotic defects and dysregulated expression of key mitotic kinases. Biochem Pharmacol. 2013 Apr 15;85(8):1104-14.

Hartley RM, Peng J, Fest GA, Dakshanamurthy S, Frantz DE, Brown ML, Mooberry SL. Polygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site. Mol Pharmacol. 2012 Mar;81(3):431-9.

Professor
Pharmacology

Education

PharmD, Pharmacology, Medical University of South Carolina, 1985

AS, Biology, St. Lawrence University, 1979

Contact

Email: MOOBERRY@UTHSCSA.EDU

Phone: 210-567-4788

Research Profile
More Info...

Graduate Students

Roma Kaul

Corena Shaffer

Nicholas F. Dybdal-Hargreaves
IMGP/Pharmacology (DDS/PhD)