Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Sudha Seshadri, M.D., DM

Sudha seshadri1 cropped

RESEARCH

Dr. Sudha Seshadri completed her M.B.B.S. from the Christian Medical College, Madras University, and her M.D. in internal medicine and D.M. in neurology from the All India Institute of Medical Sciences, New Delhi, India. Additionally, she has completed a residency in neurology at the Boston University School of Medicine and a fellowship in the neurobiology of Aging and Alzheimer Disease at the University of Massachusetts Medical Center. She has previously worked as assistant professor of neurology at the All India Institute of Medical Sciences and professor of neurology and attending neurologist at the Boston University School of Medicine.

As founding director of the Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, Dr. Seshadri will oversee, integrate, and coordinate all activities of the Biggs Institute, which will share the space of UT Health’s Barshop Institute for Longevity and Aging Studies.

Dr. Seshadri enjoys a superb reputation in both science and clinical care and is a recognized thought leader in Alzheimer’s disease having recently co-authored position papers disseminated by the National Academy of Sciences on Preventing Cognitive Decline and Dementia: A Way Forward,  and by the American Heart Association with a paper titled Defining Optimal Brain Health in Adults. She has lectured extensively, nationally and internationally, on Alzheimer’s disease, dementia and the genetics of stroke and vascular brain injury.

She is a senior investigator for the seminal Framingham Heart Study, has had peer reviewed research continuously funded by the National Institutes of Health for 10 years, and currently serves as the principal investigator on eight NIH U01 or R01 grants.

Selected Publications

(S. Adams et al., 2018; S. L. Adams et al., 2018; Behera et al., 2018; Blue et al., 2018; Brainstorm et al., 2018; Bung et al., 2018; Charidimou et al., 2018; Danduga, Reddy, Seshadri, Has, & Kumar, 2018; Davies et al., 2018; Dufouil, Beiser, Chene, & Seshadri, 2018; Ganguli et al., 2018; Huan et al., 2018; Jakhar, Linganna, & Seshadri, 2018; Malik et al., 2018; Marioni et al., 2018; Naj et al., 2018; Olson et al., 2018; Pase et al., 2018; Rajani et al., 2018; Sarnowski et al., 2018; Seshadri, Klaus, Winkowski, Kanold, & Plenz, 2018; Seshadri, Pope, & Zenewicz, 2018; S. Seshadri, W. Saab, et al., 2018; S. B. Seshadri et al., 2018; Stathopoulou et al., 2018; Sung et al., 2018; Tynkkynen et al., 2018; van der Lee et al., 2018; Vinals Gonzalez et al., 2018; Weinstein et al., 2018)

Adams, S., Conner, S., Himali, J. J., Beiser, A., Vasan, R. S., Seshadri, S., & Pase, M. P. (2018). Vascular risk factor burden and new-onset depression in the community. Prev Med, 111, 348-350. doi:10.1016/j.ypmed.2017.11.022

Adams, S. L., Benayoun, L., Tilton, K., Mellott, T. J., Seshadri, S., Blusztajn, J. K., & Delalle, I. (2018). Immunohistochemical Analysis of Activin Receptor-Like Kinase 1 (ACVRL1/ALK1) Expression in the Rat and Human Hippocampus: Decline in CA3 During Progression of Alzheimer's Disease. J Alzheimers Dis, 63(4), 1433-1443. doi:10.3233/JAD-171065

Behera, S., Kapadia, B., Kain, V., Alamuru-Yellapragada, N. P., Murunikkara, V., Kumar, S. T., . . . Parsa, K. V. L. (2018). ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK. Biochim Biophys Acta, 1864(5 Pt A), 1702-1716. doi:10.1016/j.bbadis.2018.02.019

Blue, E. E., Bis, J. C., Dorschner, M. O., Tsuang, D. W., Barral, S. M., Beecham, G., . . . on behalf of the Alzheimer's Disease Sequencing, P. (2018). Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord, 45(1-2), 1-17. doi:10.1159/000485503

Brainstorm, C., Anttila, V., Bulik-Sullivan, B., Finucane, H. K., Walters, R. K., Bras, J., . . . Neale, B. M. (2018). Analysis of shared heritability in common disorders of the brain. Science, 360(6395). doi:10.1126/science.aap8757

Bung, N., Surepalli, S., Seshadri, S., Patel, S., Peddasomayajula, S., Kummari, L. K., . . . Misra, P. (2018). 2-[2-(4-(trifluoromethyl)phenylamino)thiazol-4-yl]acetic acid (Activator-3) is a potent activator of AMPK. Sci Rep, 8(1), 9599. doi:10.1038/s41598-018-27974-1

Charidimou, A., Shams, S., Romero, J. R., Ding, J., Veltkamp, R., Horstmann, S., . . . International, M.-M. I. (2018). Clinical significance of cerebral microbleeds on MRI: A comprehensive meta-analysis of risk of intracerebral hemorrhage, ischemic stroke, mortality, and dementia in cohort studies (v1). Int J Stroke, 13(5), 454-468. doi:10.1177/1747493017751931

Danduga, R., Reddy, D. S., Seshadri, S. M., Has, K. S. S., & Kumar, K. P. (2018). Effect of combination therapy with pramipexole and n-acetylcysteine on global cerebral ischemic reperfusion injury in rats. Iran J Basic Med Sci, 21(6), 569-576. doi:10.22038/IJBMS.2018.22647.5756

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., . . . Deary, I. J. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nat Commun, 9(1), 2098. doi:10.1038/s41467-018-04362-x

Dufouil, C., Beiser, A., Chene, G., & Seshadri, S. (2018). Are Trends in Dementia Incidence Associated With Compression in Morbidity? Evidence From The Framingham Heart Study. J Gerontol B Psychol Sci Soc Sci, 73(suppl_1), S65-S72. doi:10.1093/geronb/gby001

Ganguli, M., Albanese, E., Seshadri, S., Bennett, D. A., Lyketsos, C., Kukull, W. A., . . . Hendrie, H. C. (2018). Population Neuroscience: Dementia Epidemiology Serving Precision Medicine and Population Health. Alzheimer Dis Assoc Disord, 32(1), 1-9. doi:10.1097/WAD.0000000000000237

Huan, T., Chen, G., Liu, C., Bhattacharya, A., Rong, J., Chen, B. H., . . . Levy, D. (2018). Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits. Aging Cell, 17(1). doi:10.1111/acel.12687

Jakhar, J., Linganna, S., & Seshadri, S. P. (2018). Very early onset schizophrenia diagnostic challenge and cognitive remediation-A case report. Asian J Psychiatr, 33, 61-62. doi:10.1016/j.ajp.2017.10.020

Malik, R., Chauhan, G., Traylor, M., Sargurupremraj, M., Okada, Y., Mishra, A., . . . Consortium, M. (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat Genet, 50(4), 524-537. doi:10.1038/s41588-018-0058-3

Marioni, R. E., McRae, A. F., Bressler, J., Colicino, E., Hannon, E., Li, S., . . . Deary, I. J. (2018). Meta-analysis of epigenome-wide association studies of cognitive abilities. Mol Psychiatry. doi:10.1038/s41380-017-0008-y

Naj, A. C., Lin, H., Vardarajan, B. N., White, S., Lancour, D., Ma, Y., . . . DeStefano, A. L. (2018). Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project. Genomics. doi:10.1016/j.ygeno.2018.05.004

Olson, N. C., Raffield, L. M., Lange, L. A., Lange, E. M., Longstreth, W. T., Jr., Chauhan, G., . . . Tracy, R. P. (2018). Associations of activated coagulation factor VII and factor VIIa-antithrombin levels with genome-wide polymorphisms and cardiovascular disease risk. J Thromb Haemost, 16(1), 19-30. doi:10.1111/jth.13899

Pase, M. P., Himali, J. J., Grima, N. A., Beiser, A. S., Satizabal, C. L., Aparicio, H. J., . . . Seshadri, S. (2018). Author response: Sleep architecture and the risk of incident dementia in the community. Neurology, 90(10), 487. doi:10.1212/WNL.0000000000005047

Rajani, R. M., Quick, S., Ruigrok, S. R., Graham, D., Harris, S. E., Verhaaren, B. F. J., . . . Williams, A. (2018). Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Sci Transl Med, 10(448). doi:10.1126/scitranslmed.aam9507

Sarnowski, C., Satizabal, C. L., DeCarli, C., Pitsillides, A. N., Cupples, L. A., Vasan, R. S., . . . Group, T. O. N. W. (2018). Whole genome sequence analyses of brain imaging measures in the Framingham Study. Neurology, 90(3), e188-e196. doi:10.1212/WNL.0000000000004820

Seshadri, S., Klaus, A., Winkowski, D. E., Kanold, P. O., & Plenz, D. (2018). Altered avalanche dynamics in a developmental NMDAR hypofunction model of cognitive impairment. Transl Psychiatry, 8(1), 3. doi:10.1038/s41398-017-0060-z

Seshadri, S., Pope, R. L., & Zenewicz, L. A. (2018). Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production. J Immunol. doi:10.4049/jimmunol.1800484

Seshadri, S., Saab, W., Exeter, H., Drew, E., Petrie, A., Davies, M., & Serhal, P. (2018). Clinical outcomes of a vitrified donor oocyte programme: A single UK centre experience. Eur J Obstet Gynecol Reprod Biol, 225, 136-140. doi:10.1016/j.ejogrb.2018.04.017

Seshadri, S. B., Nolan, M. M., Tutuncu, G., Forrester, J. S., Sapper, E., Esteves, G., . . . Jones, J. L. (2018). Unexpectedly high piezoelectricity of Sm-doped lead zirconate titanate in the Curie point region. Sci Rep, 8(1), 4120. doi:10.1038/s41598-018-22566-5

Stathopoulou, M. G., Xie, T., Ruggiero, D., Chatelin, J., Rancier, M., Weryha, G., . . . Consortium, V. (2018). A transnational collaborative network dedicated to the study and applications of the vascular endothelial growth factor-A in medical practice: the VEGF Consortium. Clin Chem Lab Med, 56(4), 83-86. doi:10.1515/cclm-2017-0838

Sung, Y. J., Winkler, T. W., de Las Fuentes, L., Bentley, A. R., Brown, M. R., Kraja, A. T., . . . Chasman, D. I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. Am J Hum Genet, 102(3), 375-400. doi:10.1016/j.ajhg.2018.01.015

Tynkkynen, J., Chouraki, V., van der Lee, S. J., Hernesniemi, J., Yang, Q., Li, S., . . . Salomaa, V. (2018). Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts. Alzheimers Dement, 14(6), 723-733. doi:10.1016/j.jalz.2018.01.003

van der Lee, S. J., Teunissen, C. E., Pool, R., Shipley, M. J., Teumer, A., Chouraki, V., . . . van Duijn, C. M. (2018). Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimers Dement, 14(6), 707-722. doi:10.1016/j.jalz.2017.11.012

Vinals Gonzalez, X., Odia, R., Cawood, S., Gaunt, M., Saab, W., Seshadri, S., & Serhal, P. (2018). Contraction behaviour reduces embryo competence in high-quality euploid blastocysts. J Assist Reprod Genet. doi:10.1007/s10815-018-1246-x

Weinstein, G., Zelber-Sagi, S., Preis, S. R., Beiser, A. S., DeCarli, C., Speliotes, E. K., . . . Seshadri, S. (2018). Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study. JAMA Neurol, 75(1), 97-104. doi:10.1001/jamaneurol.2017.3229

Satizabal, C., Beiser, A., Chouraki, V., Chêne, G., Dufouil, C., Seshadri, S. (2016). Incidence of Dementia

over Three Decades in the Framingham Heart Study. New England Journal of Medicine, 375(6),

523-532. doi: 10.1056/NEJMoa1504327

Robert R. Barker Distinguished University Professor of Neurology, Psychiatry and Cellular and Integrative Physiology

Senior Investigator, the Framingham Heart Study

Founding Director, Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases

Education

D.M., Neurology, All India Institute of Medical Sciences, 1992

M.D., Internal Medicine, All India Institute of Medical Sciences, 1988

M.B.B.S., Christian Medical College, Madras University, 1985

Contact

Email: seshadri@uthscsa.edu