Dr. Stephen Harris lab is interested in various
aspects of gene regulation since 1965. Working in Dr. Bert O’Malley lab, he proved
that estrogen induced the ovalbumin gene at the mRNA level in 1974. He has
worked on various aspects of gene regulation by growth factors and androgens
since that time.
In 1990, he began his studies of bone and teeth with Dr. Greg Mundy in San Antonio TX, and a focus on the Bmp2 and Bmp4 genes. During
that time, he also worked with Stuart Kauffman on computational and theoretical models of gene regulation at the
transcription level. In 1999, he began
various systems biology approaches in the lab to study large sets of gene
expression pattern with microarrays and regulation by Bmp2 in osteoblast
With his interest in system biology and gene
network approaches, he has spent the past two years relearning Unix commands and
simple programming with the help of several computer experts here at the UTHSCSA.
Our university has made a major
investment in expanding our next generation sequencing hardware and bioinformatics tools and he is directly helping in that effort. With Dr. Bo Demeler, we now have a
supercomputer with over 500 nodes that he routinely uses to analyze any of the NGS sequence files, with
the software packages and our own scripts we have installed on this supercomputer.
The bioinformatics tools and databases
at GEO and elsewhere now make this one of the most exciting areas in medicine
*Harris SE and Harris MA.
2002 Gene Expression profiling in Osteoblast Biology:Bioinformatic Tools.
Molecular Biology Reports 28:139-156.
Zhao M, Harris SE, Horn D, Geng Z, Nishimura R,
Mundy GR, and Chen D.(2002) Type I BMP Receptor signaling is necessary for Normal murine postnatal bone formation. J. Cell Biol. 157(6) June 19:1049-1060.
Sawhill BK, Wuensche A, and Kauffman S
(2003). A Model of Transcriptional Regulatory Networks Based on Biases in the Observed Regulation Rules. Complexity, Vol7, Issue 4, 23-40.
Guo D, Harris MA, Krishnaswamy A, and
Lichtler AC (2003). Transcriptional regulation of BMP2 activated genes in osteoblasts using gene expression microarray analysis: Role of Dlx2 and Dlx5 Transcription Factors. Frontiers in
BioScience 8: s1249-1265, September 1, 2003.
Yang W, Lu Y, Kalajzic
I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DW,
Turner CH, Robling AG, Harris SE.
(2005) Dentin matrix protein 1 gene cis-regulation: Use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J.
Biol. Chem. 280: 20680-20690.
Stout BM, Alent BJ, Pedalino P, Holbrook R, Gluhak-Heinrich J, Cui Y, Harris MA, Gemperli AC, Cochran DL, Deas DE, Harris SE. Enamel matrix derivative: protein components and osteoinductive properties. J Periodontol. 2014 Feb;85(2):e9-e17.
Zhang R, Oyajobi BO, Harris SE, Chen D, Tsao C, Deng HW, Zhao M. Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone. 2013 Jan;52(1):145-56.
Kalajzic I, Matthews BG, Torreggiani E, Harris MA, Divieti Pajevic P, Harris SE. In vitro and in vivo approaches to study osteocyte biology. Bone. 2013 Jun;54(2):296-306.