Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Stephen E. Harris, Ph.D.

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RESEARCH

Dr. Stephen Harris lab is interested in various aspects of gene regulation since 1965. Working in Dr. Bert O’Malley lab, he proved that estrogen induced the ovalbumin gene at the mRNA level in 1974. He has worked on various aspects of gene regulation by growth factors and androgens since that time. 

In 1990, he began his studies of bone and teeth with Dr. Greg Mundy in San Antonio TX, and a focus on the Bmp2 and Bmp4 genes. During that time, he also worked with Stuart Kauffman on computational and theoretical models of gene regulation at the transcription level. In 1999, he began various systems biology approaches in the lab to study large sets of gene expression pattern with microarrays and regulation by Bmp2 in osteoblast models. 

With his interest in system biology and gene network approaches, he has spent the past two years relearning Unix commands and simple programming with the help of several computer experts here at the UTHSCSA. Our university has made a major investment in expanding our next generation sequencing hardware and bioinformatics tools and he is directly helping in that effort. With Dr. Bo Demeler, we now have a supercomputer with over 500 nodes that he routinely uses to analyze any of the NGS sequence files, with the software packages and our own scripts we have installed on this supercomputer. The bioinformatics tools and databases at GEO and elsewhere now make this one of the most exciting areas in medicine and biology. 

Selected Publications

*Harris SE and Harris MA. 2002 Gene Expression profiling in Osteoblast Biology:Bioinformatic Tools. Molecular Biology Reports 28:139-156.

Zhao M, Harris SE, Horn D, Geng Z, Nishimura R, Mundy GR, and Chen D.(2002) Type I BMP Receptor signaling is necessary for Normal murine postnatal bone formation. J. Cell Biol. 157(6) June 19:1049-1060.

*Harris SE, Sawhill BK, Wuensche A, and Kauffman S (2003). A Model of Transcriptional Regulatory Networks Based on Biases in the Observed Regulation Rules. Complexity, Vol7, Issue 4, 23-40.

*Harris SE, Guo D, Harris MA, Krishnaswamy A, and Lichtler AC (2003). Transcriptional regulation of BMP2 activated genes in osteoblasts using gene expression microarray analysis: Role of Dlx2 and Dlx5 Transcription Factors. Frontiers in BioScience 8: s1249-1265, September 1, 2003.

Yang W, Lu Y, Kalajzic I, Guo D, Harris MA, Gluhak-Heinrich J, Kotha S, Bonewald LF, Feng JQ, Rowe DW, Turner CH, Robling AG, Harris SE. (2005) Dentin matrix protein 1 gene cis-regulation: Use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo. J. Biol. Chem. 280: 20680-20690.

Stout BM, Alent BJ, Pedalino P, Holbrook R, Gluhak-Heinrich J, Cui Y, Harris MA, Gemperli AC, Cochran DL, Deas DE, Harris SE. Enamel matrix derivative: protein components and osteoinductive properties. J Periodontol. 2014 Feb;85(2):e9-e17.

Zhang R, Oyajobi BO, Harris SE, Chen D, Tsao C, Deng HW, Zhao M. Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. Bone. 2013 Jan;52(1):145-56.

Kalajzic I, Matthews BG, Torreggiani E, Harris MA, Divieti Pajevic P, Harris SE. In vitro and in vivo approaches to study osteocyte biology. Bone. 2013 Jun;54(2):296-306.

Professor
Periodontics

Education

Ph.D., Biochemical Embryology, University of Texas at Austin, 1969

M.A., Biochemical Genetics, University of Texas at Austin, 1966

B.A., Zoology, University of Texas at Austin, 1965

Contact

Email: HARRIS@UTHSCSA.EDU

Phone: (210) 567-3723

Research Profile
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