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Search Program Faculty/Research

Shane L. Rea, Ph.D.

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RESEARCH

Dr. Shane Rea's laboratory utilizes the nematode Caenorhabditis elegans (Figure 1) as a facile model organism to help us understand the fundamental mechanisms of aging and mitochondrial dysfunction in humans (Rea et al., 2010). Research spanning three decades has revealed that nematode lifespan is controlled by a roughly equal mix of genetics, environment and random factors. The genetic toolbox of C. elegans is extensive and many genes in worms are now known that influence lifespan. Likewise, the ability to culture hundreds of thousands of genetically identical individuals in controlled environments has permitted identification of multiple environmental factors that influence aging. Such approaches have also provided insight into “random” aging factors, intractable in most other organisms (Rea et al., 2005).

Selected Publications

Butler JA, Mishur RJ, Bhaskaran S, Rea SL. A metabolic signature for long life in the Caenorhabditis elegans Mit mutants. Aging Cell. 2013 Feb;12(1):130-8.

Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condò I, Bei R, Exp Gerontol. 2013 Feb;48(2):191-201., Braeckman BP, Tavernarakis N, Testi R, Ventura N. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 2013 Feb;48(2):191-201.

Mishur RJ, Butler JA, Rea SL. Exometabolomic mapping of Caenorhabditis elegans: a tool to noninvasively investigate aging. Methods Mol Biol. 2013;1048:195-213.

Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condò I, Bei R, Rea SL, Braeckman BP, Tavernarakis N, Testi R, Ventura N. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 2013 Feb;48(2):191-201.

Khan MH, Ligon M, Hussey LR, Hufnal B, Farber R 2nd, Munkácsy E, Rodriguez A, Dillow A, Kahlig E, Rea SL. TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants. Aging (Albany NY). 2013 Oct;5(10):741-58.
 

Assistant Professor
Barshop Institute

Department of Cellular and Integrative Physiology

Education

Ph.D., Molecular Biology/Physiology, Centre for Molecular and Cellular Biology, University of Queensland, 2000

B.S., Molecular Biology, University of Queensland, 1993

B.S., Biochemistry/Chemistry, University of Queensland, 1992

Contact

Email: REAS3@UTHSCSA.EDU

Phone: (210) 562-5092

Research Profile
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