Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Shamimunisa B. Mustafa, Ph.D.

P1030580

RESEARCH

Dr. Shamimunisa B. Mustafa lab's research interests primarily lie in the area of regulation of lung epithelial ion transport via sodium channels. 

They are interested in the regulation of sodium channels by synthetic glucocorticoids, cAMP, and proinflammatory mediators. Another main area of interest is the effects of synthetic analogs of dexamethasone in the premature lung. The use of postnatal dex to alleviate respiratory disease in premature babies is limited because of the long-term growth retardation of the developing lung and associated neurological defecits in children that were exposed to postnatal dex as preterm babies. 

The synthetic analogs are currently being assessed in non-human primate lung tissue, mainly they are looking at the efficacy of these agents in elevating markers of lung maturation, e.g. surfactant associated proteins and sodium channels. 

In early preterm lung tissue, they are also investigating the effect of these analogs on angiogenic growth factors which are known to promote lung development, in particular, alveolarization. 

They are also pursuing the area of lung development in caveolin-1 deficient newborn mice, as these mice, as adults are highly susceptible to respiratory infection and do present with lung disease similar to the human lung diseases of COPD and pulmonary fibrosis.

Selected Publications

Jupelli M, Murthy AK, Chaganty BK, Guentzel MN, Selby DM, Vasquez MM, Mustafa SB, Henson BM, Seidner SR, Zhong G, Arulanandam BP. Neonatal chlamydial pneumonia induces altered respiratory structure and function lasting into adult life. Lab Invest. 2011 Oct;91(10):1530-9.

Vasquez MM, Mustafa SB, Choudary A, Seidner SR, Castro R. Regulation of epithelial Na+ channel (ENaC) in the salivary cell line SMG-C6. Exp Biol Med (Maywood). 2009 May;234(5):522-31.

Mustafa SB, Castro R, Falck AJ, Petershack JA, Henson BM, Mendoza YM, Choudary A, Seidner SR. Protein kinase A and mitogen-activated protein kinase pathways mediate cAMP induction of alpha-epithelial Na+ channels (alpha-ENaC). J Cell Physiol. 2008 Apr;215(1):101-10.

Kerecman J, Mustafa SB, Vasquez MM, Dixon PS, Castro R. Immunosuppressive properties of surfactant in alveolar macrophage NR8383. Inflamm Res. 2008 Mar;57(3):118-25.

Vasquez MM, Castro R, Seidner SR, Henson BM, Ashton DJ, Mustafa SB. Induction of serum- and glucocorticoid-induced kinase-1 (SGK1) by cAMP regulates increases in alpha-ENaC. J Cell Physiol. 2008 Dec;217(3):632-42.

Associate Professor
Pediatrics/Neonatology

Education

Ph.D., Biological Chemistry, University College London, 1992

B.S., Medicinal Chemistry, University College London, 1988

Contact

Email: MUSTAFA@UTHSCSA.EDU

Phone: 210-567-5222

Research Profile
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