Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Senlin Li, Ph.D.

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Dr. Senlin Li's primary research interest is to develop autologous hematopoietic stem cell transplantation (HSCT)-based cell and gene therapy, including HSC-derived macrophage gene therapy for neurodegenerative diseases such as Parkinson’s (to deliver neurotrophic factors to the brain) and atherosclerosis (to provide antiatherogenic factors per se). 

They have been developing a novel HSCT technology that is non-cytotoxic and free of risk. This invention, combined with the latest genome editing technologies (CRISPR/Cas9, in particular), will greatly increase the willingness of patients and their physicians to apply HSCT in treatment of disease. 

Their lab works to extend his approach to inherited and acquired blood/immune disorders including HIV/AIDS (by genome editing to produce CCR5-/- and thus HIV-resistant blood cells). 

With the same platform, they are also interested in blood/immune rejuvenation. Finally, they keep constant efforts to generate HSC from iPS cells.

Selected Publications

Biju KC, Zhou Q, Li G, Imam SZ, Roberts RL, Morgan WW, Clark RA, and Li SMacrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: A therapeutic strategy for Parkinson’s disease. Molecular Therapy 18:1536-1544, 2010.

Imam SZ, Zhou Q, Yamamoto A, Valente AJ, Ali SF, Bains MC, Roberts JL, Kahle PJ, Clark RA, Li SNovel Regulation of Parkin Function Through c-Abl-Mediated Tyrosine Phosphorylation: Implications for Parkinson’s Disease. Journal of Neuroscience 31: 157–163, 2011.

Li G, Biju KC, Xu X, Zhou Q, Chen C, Valente AJ, He W, Reddick RL, Freeman GL, Ahuja SS, Clark RA and Li SMacrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR-/- mice. Gene Therapy 18: 835–841, 2011.

Biju KC, Santacruza RA, Chen C, Zhou Q, Yao J, Rohrabaugh SL, Clark RA, Roberts JL, Phillips KA, Li S. Bone marrow-derived microglia based neurturin delivery protects against dopaminergic neurodegeneration in a mouse model of Parkinson‘s disease. Neurosci Lett 535:24-29, 2013.

Li X, Redus L, Chen C, Martinez PA, Strong R, Li S, and O'Connor JC. Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease. PLoS One 8: e71341, 2013.

A-Gonzalez N, Guillen JA, Gallardo G, Diaz M, de la Rosa JV, Hernandez IH, Casanova-Acebes M, Lopez F, Tabraue C, Beceiro S, Hong C, Lara PC, Andujar M, Arai S, Miyazaki T, Li S, Corbi AL, Tontonoz P, Hidalgo A, Castrillo A. The Nuclear Receptor LXRa controls the functional specialization of splenic macrophages. Nature Immunology 14: 831-839, 2013.


Medicine/Infectious Diseases



M.D., Medicine, University of Geneva School of Medicine, 1991

M.S., Medical Sciences, Haerbin Medical University, 1985

B.S., Biomedical Sciences, Shanxi Medical College, 1982



Phone: (210) 567-1905

Research Profile
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Graduate Students

Michael Guderyon