Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Sang Eun Lee, Ph.D.

Slide31 lee


The common property of cancer cells is genetic instability.  Frequent alterations of structure and chromosome numbers in cells contribute to the initiation and the progression of many types of cancer. The ultimate cure of this disease should thus come from a better understanding of the mechanisms preserving genome integrity. The overarching goal of my research program is to define cellular mechanisms to suppress genetic instability in the face of DNA damaging agents, in particular, DNA double strand breaks.

Selected Publications

Li F, Dong J, Eichmiller R, Holland C, Minca E, Prakash R, Sung P, Yong Shim E, Surtees JA, Eun Lee S. Role of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeast. EMBO J. 2013 Feb 6;32(3):461-72.

Villarreal DD, Lee K, Deem A, Shim EY, Malkova A, Lee SE. Microhomology directs diverse DNA break repair pathways and chromosomal translocations. PLoS Genet. 2012;8(11):e1003026.

Shim EY, Chung WH, Nicolette ML, Zhang Y, Davis M, Zhu Z, Paull TT, Ira G, Lee SE. Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J. 2010 Oct 6;29(19):3370-80.

Lee K, Zhang Y, Lee SE. Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations. Nature. 2008 Jul 24;454(7203):543-6.

Li F, Dong J, Pan X, Oum JH, Boeke JD, Lee SE. Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates. Mol Cell. 2008 May 9;30(3):325-35.

Molecular Medicine


Ph.D., Molecular Biology, Brown University, 1996

M.A., Molecular Biology, Seoul National University, 1990

B.A., Molecular Biology, Seoul National University, 1988



Phone: 210-562-4157

Research Profile
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Graduate Students

Supriya Sinha
Molecular Medicine (PhD)

Jun Che
IMGP/Cancer Biology (PhD)

Christopher Kim
IMGP/Cancer Biology (MD/PhD)