Dr. Robert Marciniak's research centers on the basic biology of aging and cancer,
emphasizing the interrelationship between the two. Initially we have
taken a genetic approach, and have focused on the analysis of a
progeriod disorder, Werner syndrome.
Werner syndrome is a human
autosomal recessive disorder characterized by symptoms suggestive of
premature aging and a predisposition to cancer.
Our analysis of the
molecular defect that causes Werner syndrome has led to the study of its
involvement in telomere processing. We are currently investigating the
role that the Werner syndrome helicase (WRN) may play in telomere
maintenance and how the loss of the function of this protein and
dysfunctional telomere processing - can lead to both symptoms of
premature aging and increased cancer incidence.
Siddiqa A, Cavazos D, Chavez J, Long L, Marciniak RA. Modulation
of telomeres in alternative lengthening of telomeres type I like human
cells by the expression of werner protein and telomerase. J Oncol. 2012;2012:806382.
Friedrichs W, Ruparel SB, Marciniak RA, deGraffenried L. Omega-3 fatty acid inhibition of prostate cancer progression to hormone independence is associated with suppression of mTOR signaling and androgen receptor expression. Nutr Cancer. 2011;63(5):771-7.
Siddiqa A, Long LM, Li L, Marciniak RA, Kazhdan I. Expression of HER-2 in MCF-7 breast cancer cells modulates anti-apoptotic proteins Survivin and Bcl-2 via the extracellular signal-related kinase (ERK) and phosphoinositide-3 kinase (PI3K) signalling pathways. BMC Cancer. 2008 May 2;8:129.
Siddiqa A, Marciniak R. Targeting the hallmarks of cancer. Cancer Biol Ther. 2008 May;7(5):740-1.
Silva J, Cavazos DA, Donzis E, Friedrichs WE, Marciniak R, deGraffenried LA. Akt-induced tamoxifen resistance is associated with altered FKHR regulation. Cancer Invest. 2007;25(7):569-73.