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Search Program Faculty/Research

Robert E. Lanford, Ph.D.

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RESEARCH

The laboratory of Robert Lanford is involved in three research programs involving hepatitis B virus (HBV), hepatitis C virus (HCV) and GBV-B, a surrogate model for HCV. One of the primary focuses of Lanford’s research program is to better understand the interactions of the hepatitis virus with the host, and how it influences either viral clearance or persistence and disease progression. The chimpanzee is the only animal other than man susceptible to infection with HCV, thus Lanford has studied this animal model extensively. Using DNA microarray technology, his team currently examines liver tissue from HCV-infected chimpanzees for changes in expression due to viral replication of 47,000 genes and the immune response to viral infection. Within days of infection, hundreds of interferon response genes are increased in expression in the liver. Although the virus manages to persist in the liver, the host limits the spread of the virus such that only a minor fraction of hepatocytes are infected. The data suggest that the mechanism of viral clearance during a successful immune response is dependent on both the innate and adaptive T cell response. In a multi-institute collaboration, Lanford recently compared the immune response to HCV and hepatitis A virus (HAV), a virus with many similarities to HCV, but differs in that it never induces chronic infection. Remarkably, they discovered that during HAV infections little to no induction of interferon response genes occurs in the liver (Fig). Thus, the virus that evades the innate immune response is always cleared and the one that induces a robust innate immune response often causes chronic infection. These studies highlight the limitations of our understanding of how HCV persist in the liver, and the need for research on persistent viral infections to aid in vaccine development. 

Selected Publications

Zubkova I, Duan H, Wells F, Mostowski H, Chang E, Pirollo K, Krawczynski K, Lanford R, Major M. Hepatitis C virus clearance correlates with HLA-DR expression on proliferating CD8+ T cells in immune-primed chimpanzees. Hepatology. 2014 Mar;59(3):803-13.

Feng Z, Hensley L, McKnight KL, Hu F, Madden V, Ping L, Jeong SH, Walker C, Lanford RE, Lemon SM. A pathogenic picornavirus acquires an envelope by hijacking cellular membranes. Nature. 2013 Apr 18;496(7445):367-71.

Lanford RE, Guerra B, Chavez D, Giavedoni L, Hodara VL, Brasky KM, Fosdick A, Frey CR, Zheng J, Wolfgang G, Halcomb RL, Tumas DB. GS-9620, an oral agonist of Toll-like receptor-7, induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees. Gastroenterology. 2013 Jun;144(7):1508-17, 1517.e1-10.

Yu G, Yagi S, Carrion R Jr, Chen EC, Liu M, Brasky KM, Lanford RE, Kelly KR, Bales KL, Schnurr DP, Canfield DR, Patterson JL, Chiu CY. Experimental cross-species infection of common marmosets by titi monkey adenovirus. PLoS One. 2013 Jul 24;8(7):e68558.

Spaniel C, Honda M, Selitsky SR, Yamane D, Shimakami T, Kaneko S, Lanford RE, Lemon SM. microRNA-122 abundance in hepatocellular carcinoma and non-tumor liver tissue from Japanese patients with persistent HCV versus HBV infection. PLoS One. 2013 Oct 9;8(10):e76867.

Scientist
Virology & Immunology
Texas Biomedical Research Institute

Education

Ph.D., Virology and Epidemiology, Baylor College of Medicine Houston, 1979

Contact

Email: RLANFORD@TXBIOMED.ORG

Phone: 210-258-9445

Research Profile
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