Dr. Robert Davey works at the Department of Virology and Immunology at the Texas Biomedical Research Institute. His research focuses on developing and optimizing an alternative workflow for identification of drugs for high containment pathogens.
His lab has developed semi-automated approaches to drug screening that are safe, efficient and work at high containment. These include a microscope system that can automatically take photos of infected cells in 96 and 384-well plates as well as computer software that they have customized to automatically identify infected cells and determine drug efficacy.
They are currently working on an ongoing project with a major drug screening facility at the National Institutes of Health. The goal of this project is to identify new drugs against Marburg (cousin of Ebola virus) and Lassa Fever viruses.
Chen Z, Kolokoltsov AA, Wang J, Adhikary S, Lorinczi M, Elferink L, Davey RA. GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding. J Virol 86: 1421-32, 2012
Kolokoltsov AA, Adhikary S, Garver J, Johnson L, Davey RA, Vela EM. Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin. Arch Virol 157: 121-7, 2012.