Dr. Rita Ghosh's lab research looks at gene-environment interactions that lead to oxidative stress in cancer and to develop ways to target these deregulated pathways as targets for cancer prevention/therapy.
The lab uses a variety of cell culture and animal models (immunocompromised and transgenic rodents) in our research. Our in vitro studies use a combination of genomic, biochemical and molecular biology approaches to study cancers including melanoma, bladder and prostate cancers. Our candidate compounds are of botanical origin including those that are used as culinary spices. We have created many derivatives of such compounds to test structure-activity of compounds for potential anti-cancer activities.
Li G, Rivas P, Bedolla R, Thapa D, Reddick RL, Ghosh R, Kumar AP. Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis. Cancer Prev Res (Phila). 2013 Jan;6(1):27-39.
Cardenas E, Ghosh R. Vitamin E: a dark horse at the crossroad of cancer management. Biochem Pharmacol. 2013 Oct 1;86(7):845-52.
Thapa D, Ghosh R. Antioxidants for prostate cancer chemoprevention: challenges and opportunities.
Bedolla RG, Gong J, Prihoda TJ, Yeh IT, Thompson IM, Ghosh R, Kumar AP. Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence. PLoS One. 2012;7(9):e44917.
Payton F, Bose R, Alworth WL, Kumar AP, Ghosh R. 4-Methylcatechol-induced oxidative stress induces intrinsic apoptotic pathway in metastatic melanoma cells. Biochem Pharmacol. 2011 May 15;81(10):1211-8.