The Lamb Lab studies
the Behavioral Biology of alcohol and drug addiction. While recently we
have begun to use behavioral genetic approaches, this work primarily involves
behavioral pharmacological approaches. Behavioral Pharmacology is an
inherently cross-disciplinary field. Its basis in Pharmacology and the
Experimental Analysis of Behavior makes it an approach that is very conducive
to translational research, and many investigators trained in Behavioral
Pharmacology have at one time or another conducted both clinical and basic
research. The lab’s recent work with rats, mice and pigeons has centered
on studying behavioral mechanisms that might be involved in addiction or that
might be responsible for medication effectiveness. The later potentially
make such studies very useful in drug development.
Lamb RJ, Pinkston JW, Daws LC. Ethanol effects on multiple fixed-interval, fixed-ratio responding in mice with deletions of the serotonin transporter gene. Behav Pharmacol. 2014 Feb;25(1):92-5.
Lamb RJ, Daws LC. Ethanol self-administration in serotonin transporter knockout mice: unconstrained demand and elasticity. Genes Brain Behav. 2013 Oct;12(7):741-7.
Ginsburg BC, Lamb RJ. A history of alternative reinforcement reduces stimulus generalization of ethanol-seeking in a rat recovery model. Drug Alcohol Depend. 2013 Apr 1;129(1-2):94-101.
Romanowich P, Lamb RJ. The effects of chlordiazepoxide and d-amphetamine during a three-component multiple schedule. J Exp Anal Behav. 2013 Jul;100(1):88-101.
Pinkston JW, Lamb RJ. Delay discounting in C57BL/6J and DBA/2J mice: adolescent-limited and life-persistent patterns of impulsivity. Behav Neurosci. 2011 Apr;125(2):194-201.