Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Reto Asmis, Ph.D.

Asmis reto lab

RESEARCH

Monocyte and macrophage dysfunction has emerged as a fundamental process common to many chronic inflammation diseases and most complications associated with metabolic disorders, and thus has become a major focus for the design of new pharmacological and therapeutic interventions. 

Dr. Reto Asmis's lab employs a wide array of biochemical, cell biological, imaging, and translational approaches to explore novel aspects of macrophage biology in the context of human vascular diseases and diabetic complications. 

Our approach is to build on fundamental discoveries at the molecular and cellular level and to translate these into animal models and ultimately, into patient settings.


Selected Publications

Kim, H.S., Ullevig, L.S., Zamora, D. Lee, C.F. and Asmis, R. Redox Regulation of MAPK Phosphatase 1 Controls Monocyte Migration and Macrophage Recruitment. Proc.Natl.Acad.Sci., 109, E2803-12 (2012)

Lee CF, Qiao M, Schröder K, Zhao Q, Asmis R. Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death. Circ Res. 2010 May 14;106(9):1489-97.

Ullevig, S., Zhao, Q., Zamora, D. and Asmis, R. Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis. Atherosclerosis, 219, 409-16 (2011).

Ullevig, S., Zhao, Q., Lee, C.F., Kim, H.S., Zamora, D. and Asmis, R. NADPH Oxidase 4 Mediates Monocyte Priming and Accelerated Chemotaxis Induced by Metabolic Stress. Arterioscler. Thromb.Vasc.Biol., 32, 415-26 (2012).

Tavakoli S, Zamora D, Ullevig S, Asmis R. Bioenergetic profiles diverge during macrophage polarization: implications for the interpretation of 18F-FDG PET imaging of atherosclerosis. J Nucl Med. 2013 Sep;54(9):1661-7.

Professor, Clinical Laboratory Science

Biochemistry and Structural Biology

Education

Ph.D., Biochemistry, University of Fribourg, Switzerland, 1989

M.S., Organic Chemistry and Biochemistry, University of Fribourg, Switzerland, 1984

Contact

Email: ASMIS@UTHSCSA.EDU
Phone: (210) 567-3711

Research Profile
More info...

Graduate Students

Huynh Nga Nguyen

IMGP/Molecular Biophysics & Biochemistry (Ph.D.)

Kevin Downs, M.S. 
IMGP/Genetics, Genomics, & Development (Ph.D.)