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Search Program Faculty/Research

Ralph A. DeFronzo, M.D.

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RESEARCH

Dr. Ralph DeFronzo's major interests focus on the pathogenesis and treatment of type 2 diabetes mellitus and the central role of insulin resistance in the metabolic-cardiovascular cluster of disorders known collectively as the Insulin Resistance Syndrome. Using the euglycemic insulin clamp technique in combination with radioisotope turnover methodology, limb catheterization, indirect calorimetry, and muscle biopsy, he has helped to define the biochemical and molecular disturbances responsible for insulin resistance in type 2 diabetes mellitus.

Selected Publications

Handelsman Y, Henry RR, Bloomgarden ZT, Dagogo-Jack S, DeFronzo RA, Einhorn D, Ferrannini E, Fonseca VA, Garber AJ, Grunberger G, LeRoith D, Umpierrez GE, Weir MR. AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY POSITION STATEMENT ON THE ASSOCIATION OF SGLT-2 INHIBITORS AND DIABETIC KETOACIDOSIS Endocr Pract 2016 Jun;22(6):753-762.

Tripathy D, Schwenke DC, Banerji MA, Bray GA, Buchanan TA, Clement SC, Henry RR, Kitabchi AE, Mudaliar S, Ratner RE, Stentz FB, Musi N, Reaven PD, DeFronzo RA. Diabetes incidence and glucose tolerance after termination of pioglitazone therapy: Results from ACT NOW J Clin Endocrinol Metab 2016 May;101(5):2056-2062.

DeFronzo RA, MD, Chilton R, MD, Norton L, Geoffrey Clarke G, Ryder REJ, Abdul-Ghani M. Revitalization of pioglitazone: the optimal agent to be combined with an SGLT2 inhibitor Diabetes, Obesity, & Metabolism 2016 Feb;.

DeFronzo RA, Chilton R, Norton L, Clarke G, Ryder RE, Abdul-Ghani M. Revitalization of Pioglitazone: The Optimal Agent to be Combined with an SGLT2 Inhibitor Diabetes Obes Metab 2016 Feb;.

Christian Fuchsberger , Jason Flannick , Kyle Gaulton , Vineeta Agarwala , Hyun Min Kang , Pierre Fontanillas , Noel Burtt , Clement Ma , Thomas Blackwell , Adam Locke , Davis McCarthy , Loukas Moutsianas , Christopher Hartl , Michael Stitzel , Stephen Parker , Richard Pearson , Ashish Kumar , Peter Chines , Anne Jackson , Heather Stringham , Tanya Teslovich , Jeroen Huyghe , Xueling Sim , Yuhui Chen , John Perry , Nigel Rayner , Neil Robertson , Manuel Rivas , Andrew Morris , Benjamin Voight , Cecilia Lindgren , Martijn van de Bunt , Anubha Mahajan , Todd Green , Claes Ladenvall , Jo?o Fadista , Jasmina Kravic , Valeriya Lyssenko , Lori Bonnycastle , Leena Kinnunen , Narisu Narisu , Amy Swift , Kerrin Small , Katharine Owen , Christopher Groves , Michael Roden , Werner Rathmann , Christian Herder , Leif Groop , Peter Nilsson , Tiinamaija Tuomi , Jaakko tuomilehto , Francis Collins , Richard Watanabe , Richard Bergman , Andrew Hattersley , Tim Frayling , Tim Spector , Konstantin Strauch , Annette Peters , Christian Gieger , Ruth Loos , Erwin Bottinger , Yingchang Lu , Omri Gottesman , Andres Metspalu , Erik Ingelsson , Lars Lind , Phoenix Kwan , Robert Sladek , Philippe Froguel , Loic Yengo , Dorothy Thuillier , Pablo Cingolani , Reedik Magi , Evelin Mihailov , James Meigs , Josee Dupuis , Han Chen , Denis Rybin , Thomas Meitinger , Thomas Illig , Harald Grallert , Martina Mueller , Ann-Christine Syvanen , Vilmantas Giedraitis , Mark Seielstad , Ravindranath Duggirala , John Blangero , Craig Hanis , Nancy Cox , Graeme Bell , Stacey Gabriel , Eric Lander , Ryan Poplin , Eric Banks , Jared Maguire , Khalid Shakir , Timothy Fennell , Mark DePristo , David Buck , Gemma Buck , Joseph Trakalo , Janina Ried , Cornelia Huth , Jose Florez , Karen Mohlke , Gilean McVean , Laura Scott , Goncalo Abecasis , Peter Donnelly , Inga Prokopenko , Tim Strom , Mark McCarthy , David Altshuler , Barbara Thorand , Christa Meisinger , Martin Hrabe de Angelis , Claudia Langenberg , Robert Scott , Nicholas Wareham , Beverley Balkau , Heiner Boeing , Paul Franks , Carmen Navarro , Domenico Palli , Yvonne van der Schouw , Andrew Morris , Heikki Koistinen , Hanna Abboud , Ralph DeFronzo , Alisa Manning , Rector Ayra , Barry Freedman , Adolfo Correa , Alex Doney , Alena StanĨakova , Cheng Hu , Allan Linneberg , Anders Rosengren , Andrew Farmer , Anette Gjesing , Anna Gloyn , Annemari Karajamaki , Young Jin Kim , Andrew Wood , Adam Butterworth , Tin Aung , Benjamin Glaser , Benjamin Lehne , Benjamin Neale , Bo Isomaa , Bok-Ghee Han , Mauricio Carneiro , Giriraj Chandak , Ching-Yu Cheng , Christine Blancher , Christopher Jenkinson , Claudia Tam , Colin Palmer , Cramer Christensen , Joanne Curran , David Aguilar , Dwaipayan Bharadwaj , Donald Bowden , Selyeong Lee , Dorota Pasko , Dorairaj Prabhakaran , Dylan Hodgkiss , Edmund Chan , Eleftheria Zeggini , Eric Gamazon , E Shyong Tai , Yossi Farjoun , Farook Thameem , Teresa Ferreira , Sharon Fowler , Frank Hu , Fredrik Karpe. The genetic architecture of type 2 diabetes Nature 2016 Jan;.

699.DeFronzo RA, Buse JB, Kim T, Burns C, Skare S, Baron A, Fineman M. Once-daily delayed-release metformin lowers plasma glucose and enhances fasting and postprandial GLP-1 and PYY Diabetologia 2016 Jan;59:1645-1654.

700.Wilding JPH, Rajeev SP, DeFronzo RA. Positioning SGLT2 inhibitors/incretin based therapies in the treatment algorithm Diabetes Care 2016 Jan;39:S154-S164.

Abdul-Ghani M, DeFronzo RA, Jayyousi A. Pre-diabetes and risk of diabetes and associated complications ? impaired fasting glucose vs impaired glucose tolerance: does it matter? 2016 Jul 6 [Epub ahead of print] Curr Opin Clin Nutr Metabolic Care 2016 Jan;.

Daniele G, Xiong J, Merovci A, Eldor R, Tripathy D, DeFronzo RA, Norton L, Abdul-Ghani M. Dapagliflozin enhances fat oxidation but decreases mitochondrial ATP synthesis rate in type 2 diabetes patients (accepted) Diabetes Care 2016 Jan;.

Daniele G, Eldor R, Huerta C, Alatrach M, Adams J, DeFronzo RA, Duong T, Lancaster J, Zirie M, Jayyousi A, Abdul-Ghani M. Discordance between central (brain) and pancreatic action of exenatide in lean and obese subjects (in press) Diabetes Care 2016 Jan;.

Buse J, DeFronzo RA, Rosenstock J, Kim T, Burns C, Skare S, Baron A, Fineman M. The primary glucose-lowering effect of metformin resides in the gut not the circulation. Results from short-term pharmacokinetic and 12-week dose ranging studies Diabetes Care 2016 Jan;39:198-205.

Merovci A, Abdul-Ghani M, Mari A, Solis-Herrera C, Xiong J, Daniele G, Tripathy D, DeFronzo RA. Effect of dapagliflozin with and without acipimox on insulin sensitivity and insulin secretion in T2DM individuals JCEM 2016 Jan;.

Abdul-Ghani M, Del Prato S, Chilton R, DeFronzo RA. SGLT2 inhibitors and cardiovascular risk: lessons learned from the EPMA-REG OUTCOME trial. (Accepted for Publication) Diabetes Care 2016 Jan;39:717-725.

Doiron B, Hu W, DeFronzo RA. Beta Cell Formation in vivo Through Cellular Networking, Integration and Processing (CNIP) in Wild Type Adult Mice Curr Pharm Biotechnol 2016 Jan;17(4):376-388.

Garber AJ, Abrahamson MJ, Barzilay JI, Blonde L, Bloomgarden ZT, Bush MA, Dagogo-Jack S, DeFronzo RA, Einhorn D, Fonseca VA, Garber JR, Garvey WT, Grunberger G, Handelsman Y, Henry RR, Hirsch IB, Jellinger PS, McGill JB, Mechanick JI, Rosenblit PD, Umpierrez GE. CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM - 2016 EXECUTIVE SUMMARY Endocr Pract 2016 Jan;22(1):84-113.

Muscogiuri G, Daniele G, DeFronzo R, Gastaldelli A, Holst JJ. GLP-1 and central/peripheral nervous system: a key cross talk in type 2 diabetes (accepted) Nature Rev Endocrinol 2016 Jan;.

Professor & Division Chief
Medicine/Diabetes

Education

M.D., Medicine, Harvard Medical School, 1969

M.S., Medicine, Boston College Graduate School of Biology, 1969

BMS, Medicine, Dartmouth Medical School

B.S., Biology/Biochemistry, Yale University, 1964

Contact

Email: DEFRONZO@UTHSCSA.EDU

Phone: (210) 567-6691

Research Profile
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