The long-range objective of Dr. Tekmal’s research is to elucidate the role of hormones
and growth factors and their receptors in the initiation and progression of breast,
cervical and ovarian cancers.
Using our novel aromatase transgenic mice model we
have demonstrated for the first time that increased mammary estrogens leads to the
induction of various preneoplastic and neoplastic changes that are similar to early
Ongoing studies focus on cross-talk between local estrogen/estrogen
receptor-mediated action with oncogenes, growth factors, and tumor suppressor genes
to initiate/promote breast cancer as well as design and testing of novel therapeutic
approaches for the prevention and treatment of breast, cervical and ovarian cancers
using both in vivo and in vitro model systems.
Bhaskaran S, Dileep KV, Deepa SS, Sadasivan C, Klausner M, Krishnegowda NK, Tekmal RR, VandeBerg JL, Nair HB. Gossypin
as a novel selective dual inhibitor of V-RAF murine sarcoma viral
oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma. Mol Cancer Ther. 2013 Apr;12(4):361-72.
Roy SS, Gonugunta VK, Bandyopadhyay A, Rao MK, Goodall GJ, Sun LZ, Tekmal RR, Vadlamudi RK. Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer. Oncogene. 2013 Aug 26.
Roy S, Chakravarty D, Cortez V, De Mukhopadhyay K, Bandyopadhyay A, Ahn JM, Raj GV, Tekmal RR, Sun L, Vadlamudi RK. Significance of PELP1 in ER-negative breast cancer metastasis. Mol Cancer Res. 2012 Jan;10(1):25-33.
Nair HB, Perla RP, Kirma NB, Krishnegowda NK, Ganapathy M, Rajhans R, Nair SS, Saikumar P, Vadlamudi RK, Tekmal RR. Estrogen
receptor-beta mediates the protective effects of aromatase induction in
the MMTV-Her-2/neu x aromatase double transgenic mice. Horm Cancer. 2012 Apr;3(1-2):26-36.
Pradeep CR, Köstler WJ, Lauriola M, Granit RZ, Zhang F, Jacob-Hirsch J,
Rechavi G, Nair HB, Hennessy BT, Gonzalez-Angulo AM, Tekmal RR,
Ben-Porath I, Mills GB, Domany E, Yarden Y. Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. Oncogene. 2012 Feb 16;31(7):907-17.