Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Rajeshwar R. Tekmal, Ph.D.

Rajeshwar tekmal ppphoto120150310055756

RESEARCH

The long-range objective of Dr. Tekmal’s research is to elucidate the role of hormones and growth factors and their receptors in the initiation and progression of breast, cervical and ovarian cancers. 

Using our novel aromatase transgenic mice model we have demonstrated for the first time that increased mammary estrogens leads to the induction of various preneoplastic and neoplastic changes that are similar to early breast cancer. 

Ongoing studies focus on cross-talk between local estrogen/estrogen receptor-mediated action with oncogenes, growth factors, and tumor suppressor genes to initiate/promote breast cancer as well as design and testing of novel therapeutic approaches for the prevention and treatment of breast, cervical and ovarian cancers using both in vivo and in vitro model systems.

Selected Publications

Bhaskaran S, Dileep KV, Deepa SS, Sadasivan C, Klausner M, Krishnegowda NK, Tekmal RR, VandeBerg JL, Nair HB. Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma. Mol Cancer Ther. 2013 Apr;12(4):361-72.

Roy SS, Gonugunta VK, Bandyopadhyay A, Rao MK, Goodall GJ, Sun LZ, Tekmal RR, Vadlamudi RK. Significance of PELP1/HDAC2/miR-200 regulatory network in EMT and metastasis of breast cancer. Oncogene. 2013 Aug 26.

Roy S, Chakravarty D, Cortez V, De Mukhopadhyay K, Bandyopadhyay A, Ahn JM, Raj GV, Tekmal RR, Sun L, Vadlamudi RK. Significance of PELP1 in ER-negative breast cancer metastasis. Mol Cancer Res. 2012 Jan;10(1):25-33.

Nair HB, Perla RP, Kirma NB, Krishnegowda NK, Ganapathy M, Rajhans R, Nair SS, Saikumar P, Vadlamudi RK, Tekmal RR. Estrogen receptor-beta mediates the protective effects of aromatase induction in the MMTV-Her-2/neu x aromatase double transgenic mice. Horm Cancer. 2012 Apr;3(1-2):26-36.

Pradeep CR, Köstler WJ, Lauriola M, Granit RZ, Zhang F, Jacob-Hirsch J, Rechavi G, Nair HB, Hennessy BT, Gonzalez-Angulo AM, Tekmal RR, Ben-Porath I, Mills GB, Domany E, Yarden Y. Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. Oncogene. 2012 Feb 16;31(7):907-17.

Professor
Obstetrics & Gynecology

Education

Ph.D. Biochemistry, National Dairy Research Institute- Kurukshetra University, 1982

M.S., Biological Sciences, Osmania University, 1977

B.S., Biological Sciences, Osmania University, 1975

Contact

Email: TEKMAL@UTHSCSA.EDU

Phone: 210-567-4930

Research Profile
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