Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Philip LoVerde, Ph.D

Loverde photo

RESEARCH

Dr. Phillip LoVerde's lab research involves studies of host-parasite interactions of schistosomes. Our strengths are in molecular parasitology, immunoparasitology and genetics. 

They have contributed continuously to molecular studies on Schistosoma, eg in the sequence of the schistosome genome, the resequence of the genome to make it a reference genome, development of a 5 cM genetic map for S. mansoni, identification and characterization of nuclear receptors in schistosomes, and elucidated TGF signal pathways in schistosomes. 

As a collaboration, they identified the gene responsible for oxamniquine (OXA) drug resistance, worked out the mode of action of OXA and determined the structure of the enzyme (Sulfotransferase)-co-factor and drug. They identified the sulfotransferase homologues from S. haematobium and S. japonicum and are evaluating OXA derivatives for effectiveness against all human schistosome species.

Selected Publications

Chevalier, F.D., Valentim, C. L.L., LoVerde, P. T., Anderson, T.J.C. Efficient linkage mapping using exome capture and extreme QTL in schistosome parasites. BMC Genomics2013, 15:617 doi:10.1186/1471-2164-15-617

Carvalho-Queiroz, C, Nyakundi, R, Ogongo, P, Rikoi, H, Egilmez,NK, Farah, IO, Kariuki, TK, LoVerde, PTProtective potential of antioxidant enzymes as vaccines for schistosomiasis in a non-human primate model. Frontiers in Immunology, 6:273. doi: 10.3389/fimmu.2015.00273.

Valentim CL, Cioli D, Chevalier FD, Cao X, Taylor AB, Holloway SP, Pica-Mattoccia L, Guidi A, Basso A, Tsai IJ, Berriman M, Carvalho-Queiroz C, Almeida M, Aguilar H, Frantz DE, Hart PJ, LoVerde PT*, Anderson TJ*. Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites. Science. 2013 Dec 13;342(6164):1385-9. * equal contributors

Hirai H, Hirai Y, LoVerde PT. Evolution of sex chromosomes ZW of Schistosoma mansoni inferred from chromosome paint and BAC mapping analyses. Parasitol Int. 2012 Dec;61(4):684-9.

Oliveira KC, Carvalho ML, Verjovski-Almeida S, LoVerde PT. Effect of human TGF-β on the gene expression profile of Schistosoma mansoni adult worms. Mol Biochem Parasitol. 2012 Jun;183(2):132-9.

Wu W, LoVerde PT. Nuclear hormone receptors in parasitic helminths. Mol Cell Endocrinol. 2011 Mar 1;334(1-2):56-66.

Berriman M, Haas BJ, LoVerde PT, Wilson RA, Dillon GP, Cerqueira GC, Mashiyama ST, Al-Lazikani B, Andrade LF, Ashton PD, Aslett MA, Bartholomeu DC, Blandin G, Caffrey CR, Coghlan A, Coulson R, Day TA, Delcher A, DeMarco R, Djikeng A, Eyre T, Gamble JA, Ghedin E, Gu Y, Hertz-Fowler C, Hirai H, Hirai Y, Houston R, Ivens A, Johnston DA, Lacerda D, Macedo CD, McVeigh P, Ning Z, Oliveira G, Overington JP, Parkhill J, Pertea M, Pierce RJ, Protasio AV, Quail MA, Rajandream MA, Rogers J, Sajid M, Salzberg SL, Stanke M, Tivey AR, White O, Williams DL, Wortman J, Wu W, Zamanian M, Zerlotini A, Fraser-Liggett CM, Barrell BG, El-Sayed NM. The genome of the blood fluke Schistosoma mansoni. Nature. 2009 Jul 16;460(7253):352-8.

Professor
Biochemistry/Pathology

Education

Ph.D., Epidemiologic Science, University of Michigan, 1976

M.S., Epidemiologic Science, University of Michigan, 1976

M.S., Wildlife Management, University of Michigan, 1971

B.S., Zoology, University of Michigan, 1968

Contact

Email: LOVERDE@UTHSCSA.EDU

Phones: (210) 567-3737

Research Profile
More Info...

Graduate Students

Meghan Guzman

Edward Rodriguez