The research in Dr. Peter Dube's lab is focused on inflammation and how
inflammation leads to disease. In particular, we investigate how
bacterial pathogens and their products influence inflammatory responses.
The three major areas of interest are pulmonary infections leading to
asthma or the exacerbation of asthma, acute infections of the lungs by
biodefense-related pathogens and infectious gastroenteritis caused by
invasive bacterial pathogens.
Our interests in asthma revolve around Mycoplasma pneumoniae and a toxin produced by this pathogen called the Community Acquired Respiratory Distress Syndrome toxin (CARDS toxin). Mycoplasma pneumoniae
is often associated with acute exacerbations of asthma in children and
adults and recent data suggests that CARDS toxin might be linked to a
subset of asthma exacerbations.
We are currently investigating how the
CARDS toxin influences the immune system to promote asthma-like
responses. Using a variety of animal models we have been able to show
that exposure to purified CARDS toxin or low dose infection with M. pneumoiniae
leads to the development of asthma-like inflammation in naive animals
or exacerbation of asthma-like inflammation in animals with experimental
asthma. We are using these models to dissect the immunological
mechanisms responsible for generation of M. pneumoniae and CARDS toxin-associated asthma responses.
Evseev AI, Semenov I, Archer CR, Medina JL, Dube PH, Shapiro MS, Brenner R. Functional effects of KCNQ K(+) channels in airway smooth muscle. Front Physiol. 2013 Oct 7;4:277.
Bose R, Thinwa J, Chaparro P, Zhong Y, Bose S, Zhong G, Dube PH. Mitogen-activated protein kinase-dependent interleukin-1α intracrine signaling is modulated by YopP during Yersinia enterocolitica infection. Infect Immun. 2012 Jan;80(1):289-97.
Medina JL, Coalson JJ, Brooks EG, Winter VT, Chaparro A, Principe MF, Kannan TR, Baseman JB, Dube PH. Mycoplasma pneumoniae CARDS toxin induces pulmonary eosinophilic and lymphocytic inflammation. Am J Respir Cell Mol Biol. 2012 Jun;46(6):815-22.
Embry A, Meng X, Cantwell A, Dube PH, Xiang Y. Enhancement of immune response to an antigen delivered by vaccinia virus by displaying the antigen on the surface of intracellular mature virion. Vaccine. 2011 Jul 26;29(33):5331-9.
Cantwell AM, Bubeck SS, Dube PH. YopH inhibits early pro-inflammatory cytokine responses during plague pneumonia. BMC Immunol. 2010 Jun 16;11:29.