Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Pei Wang, Ph.D.

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RESEARCH

Dr. Pei Wang's lab is focused on the two major diseases of the pancreas: diabetes which involves the endocrine tissue and PDAC (pancreatic ductal adenocarcinoma), a cancer of the exocrine pancreas that is notorious for its dismal prognosis. 

The immediate goals for our research are: 1) to generate genetically engineered human pancreatic cells to model PDAC, and 2) to understand the mechanistic role of KRAS in PDAC initiation and progression.  The long-term goals are to identify markers and methods for early diagnosis of PDAC and to inform the development of effective therapeutic strategies.

The other interest of my lab is to generate insulin producing cells (IPCs) from pluripotent stem cells for modeling disease and for cell replacement therapies for diabetes. 


Selected Publications

Wang P, McKnight KD, Wong DJ, Rodriguez RT, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang HY, Kim SK. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev. 2012 Aug 10;21(12):2273-87.

Wang P, Rodriguez RT, Wang J, Ghodasara A, Kim SK. Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell. 2011 Mar 4;8(3):335-46. 

McKnight KD, Wang P, Kim SK. Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell. 2010 Apr 2;6(4):300-8.

Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H. Defectiveneuromuscular synapses in mice lacking amyloid precursor protein (APP) andAPP-Like protein 2. J Neurosci. 2005 Feb 2;25(5):1219-25.

Wang P, Pereira FA, Beasley D, Zheng H. Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development. 2003 Oct;130(20):5019-29.

Assistant Professor

Cell Systems and Anatomy

Education

Ph.D., Baylor College of Medicine, 2004

Contact

Email: WANGP3@UTHSCSA.EDU

Phone: 210-567-6796

Research Profile
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Graduate Students

Xue Yin

Cancer biology (Ph.D).