Dr. Paul Jerabek's research focuses on the synthesis and development of positron-emitting radio-pharmaceuticals for application to positron emission tomography (PET) studies.
PET has the unique ability to image biochemical and biological processes of the living human body that are fundamental to disease and understanding the normal function of various organ systems of the body. For example, PET has shown to be especially useful to image neurological and psychiatric disorders, heart disease, and cancer.
Yee SH, Lee K, Jerabek PA, Fox, PT. Quantitative measurement of oxygen metabolic rate in the rat brain using microPET imaging of briefly inhaled 15O-labelled oxygen gas. Nucl Med Commun 2006 Jul;27(7):573-581.
Yee, Seong-Hwan; Jerabek, Paul A.; Fox, Peter T. Non-invasive quantification of cerebral blood flow for rats by microPET imaging of 15O labelled water: the application of a cardiac time-activity curve for the tracer arterial input function. Nuclear Medicine Communications. 26(10):903-911, October 2005.
Ching-Mei Feng, Shalini Narayana, Jack L. Lancaster, Paul A. Jerabek, Thomas L. Arnow, Fang Zhu, Li Hai Tan, Peter T. Fox and Jia-Hong Gao. CBF changes during brain activation: fMRI vs. PET. NeuroImage 22 (2004) 443–446.
Helen S. Mayberg, J. Arturo Silva, Steven K. Brannan, Janet L. Tekell, Roderick K. Mahurin, Scott McGinnis, and Paul A. Jerabek. The Functional Neuroanatomy of the Placebo Effect. Am J Psychiatry 2002; 159: 1830-1840.
Mario Liotti, Helen S. Mayberg, Scott McGinnis, Stephen L. Brannan and Paul Jerabek. Unmasking Disease-Specific Cerebral Blood Flow Abnormalities: Mood Challenge in Patients With Remitted Unipolar Depression. Am J Psychiatry 2002; 159: 1830-1840.
Helen S. Mayberg, Mario Liotti, Stephen K. Brannan, Scott McGinnis, Roderick K. Mahurin, Paul A. Jerabek, J. Arturo Silva, Janet L. Tekell, Charles C. Martin, Jack L. Lancaster, and Peter T. Fox. Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness. Am J Psychiatry 1999; 156: 675-682.
Peter T. Fox, Roger J. Ingham, Janis C. Ingham, Traci B. Hirsch, J. Hunter Downs, Charles Martin, Paul Jerabek, Thomas Glass & Jack L. Lancaster. Imaging human intra-cerebral connectivity by PET during TMS. Neuroreport. 8(12):2787-2791, August 18, 1997.
Fox, Peter T.; Ingham, Roger J.; Ingham, Janis C.; Hirsch, Traci B.; Downs, J. Hunter; Martin, Charles; Jerabek, Paul; Glass, Thomas; Lancaster, Jack L. A PET study of the neural systems of stuttering. Nature, Volume 382, Issue 6587, pp. 158-162 (1996).
Sterrett, T. L., Jerabek, P. A., and Sachdeva, R. Protein adsorption characteristics of plasma treated polyurethane surfaces. J. Material Sci.: Materials in Med 3, 402 (1992).
Jerabek, P. A., Dence, C. S., Kilbourn, M. R., Welch, M. J., and Kadmon, D. Synthesis and uptake of no carrier-added 1-[C-11]-putrescine into rat prostate. Int. J. Nucl. Med. Biol. 12, 349 (1985).