Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Paul Fitzpatrick, Ph.D.

Img 8202

RESEARCH

Dr. Paul Fitzpatrick's lab studies the regulatory and catalytic properties of the aromatic amino acid hydroxylases tyrosine hydroxylase (TyrH) and phenylalanine hydroxylase (PheH). TyrH, the key enzyme in the biosynthesis of the catecholamine neurotransmitters, utilizes a non-heme iron atom to catalyze oxygen activation and addition. The enzyme is regulated by phosphorylation and feedback inhibition. 

PheH, an allosteric enzyme deficient in phenylketonuria, has a similar catalytic mechanism and a similar structure, but differs in its regulatory properties. We utilize a range of biochemical and biophysical techniques, from single turnover kinetics to NMR spectroscopy.


Selected Publications

Meisburger, Steve P., Taylor, Alexander B., Khan, Crystal A., Zhang, Shengnan, Fitzpatrick, Paul F., and Ando, Nozomi (2016) “Domain movements upon activation of phenylalanine hydroxylase characterized by crystallography and chromatography-coupled small-angle X-ray scattering” J. Amer. Chem. Soc. 138, 6506-6516 PMC4896396

Zhang, Shengnan, Huang, Tao, Ilangovan, Udayar, Hinck, Andrew P., and Fitzpatrick, Paul F. (2014) “The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase” J. Mol. Biol. 426, 1483-1497

Zhang, Shengnan, and Fitzpatrick, Paul F. (2016) “Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase” J. Biol. Chem. 291, 7418-7425

Fitzpatrick, Paul F. (2015) “Structural Insight into the Regulation of Aromatic Amino Acid Hydroxylation” Curr. Opinion Struct. Biol. 35, 1-6

Professor

Biochemistry and Structural Biology

Education

Ph.D., Biological Chemistry, University of Michigan, 1981

Contact

Email: FITZPATRICKP@UTHSCSA.EDU

Phone: (210) 567-8264

Research Profile
More Info...

Graduate Students

Crystal Olivas Khan
IMGP/MBB (Ph.D.)