Nathaniel A. Jeske, Ph.D.

RESEARCH

Dr. Nathan Jeske's lab conducts research on signaling mechanisms that mediate inflammatory pain. This type of pain affects every American, and can progress to chronic forms of pain that currently disable tens of millions of Americans every year. Our research identifies new scaffolding proteins that control the flow of information from one protein to another, thereby serving as a potential stopgap and promising analgesic target for further development.

Selected Publications

Weng HJ, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo GC, Wang Y, Geng Y, Zhang J, Guan Y, Akopian AN, Dong X. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain.Neuron. 2015 Feb 18;85(4):833-46. doi: 10.1016/j.neuron.2014.12.065. Epub 2015 Jan 29.

Rowan MP, Szteyn K, Doyle AP, Gomez R, Henry MA, Jeske NA.β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons. Mol Pain. 2014 Aug 1;10:50. doi: 10.1186/1744-8069-10-50.

Rowan MP, Bierbower SM, Eskander MA, Szteyn K, Por ED, Gomez R, Veldhuis N, Bunnett NW, Jeske NA.Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talk.PLoS One. 2014 Apr 2;9(4):e93688. doi: 10.1371/journal.pone.0093688. eCollection 2014.

Por ED, Bierbower SM, Berg KA, Gomez R, Akopian AN, Wetsel WC, Jeske NA.β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.J Biol Chem. 2012 Oct 26;287(44):37552-63. doi: 10.1074/jbc.M112.391847. Epub 2012 Sep 5.

Jeske NA, Por ED, Belugin S, Chaudhury S, Berg KA, Akopian AN, Henry MA, Gomez R.A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphate. J Neurosci. 2011 Jun 8;31(23):8681-8. doi: 10.1523/JNEUROSCI.0020-11.2011.

Jeske NA, Patwardhan AM, Ruparel NB, Akopian AN, Shapiro MS, Henry MA. A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1. Pain. 2009 Dec;146(3):301-7. doi: 10.1016/j.pain.2009.08.002. Epub 2009 Sep 19.

Jeske NA, Diogenes A, Ruparel NB, Fehrenbacher JC, Henry M, Akopian AN, Hargreaves KM. A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1.Pain. 2008 Sep 15;138(3):604-16. doi: 10.1016/j.pain.2008.02.022. Epub 2008 Apr 1

Por ED, Gomez R, Akopian AN, Jeske NA. Phosphorylation regulates TRPV1 association with β-arrestin-2. Biochem J. 2013 Apr 1;451(1):101-9.

Por ED, Bierbower SM, Berg KA, Gomez R, Akopian AN, Wetsel WC, Jeske NA. β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem. 2012 Oct 26;287(44):37552-63. 2.

Jeske NA. Somatosensory scaffolding structures. Front Mol Neurosci. 2012 Jan 23;5:2.

Jeske NA, Por ED, Belugin S, Chaudhury S, Berg KA, Akopian AN, Henry MA, Gomez R. A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphate.J Neurosci. 2011 Jun 8;31(23):8681-8. 

Chaudhury S, Bal M, Belugin S, Shapiro MS, Jeske NA. AKAP150-mediated TRPV1 sensitization is disrupted by calcium/calmodulin. Mol Pain. 2011 May 14;7:34.