Nathaniel A. Jeske, Ph.D.

RESEARCH

Dr. Nathan Jeske's lab conducts research on signaling mechanisms that mediate inflammatory pain and analgesia. Over 100 million Americans suffer from pain annually, and understanding how this sensation graduates to a chronic state, as well as how to treat it efficaciously, are the primary research goals of the Jeske lab. Research in the Jeske lab focuses on biochemical signaling molecules and pathways unique to pain-sensing neurons in the periphery that can be targeted to reduce pain, increase analgesia, and improve the quality of life for pain patients. Researchers combine molecular, biochemical, pharmacological, physiological, and behavioral studies with opportunities for human clinical expertise to provide comprehensive approaches to some of our most important issues related to pain and analgesia in our current society.

Selected Publications 

A-Kinase Anchoring Protein 79/150 Scaffolds Transient Receptor Potential A 1 Phosphorylation and Sensitization by Metabotropic Glutamate Receptor Activation.

Brackley AD, Gomez R, Guerrero KA, Akopian AN, Glucksman MJ, Du J, Carlton SM, Jeske NA.

Sci Rep. 2017 May 12;7(1):1842. doi: 10.1038/s41598-017-01999-4.

GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity.

Brackley AD, Gomez R, Akopian AN, Henry MA, Jeske NA.

Cell Rep. 2016 Sep 6;16(10):2686-2698. doi: 10.1016/j.celrep.2016.07.084. Epub 2016 Aug 25.

Identification of a signaling cascade that maintains constitutive δ-opioid receptor incompetence in peripheral sensory neurons.

Brackley AD, Sarrami S, Gomez R, Guerrero KA, Jeske NA.

J Biol Chem. 2017 May 26;292(21):8762-8772. doi: 10.1074/jbc.M117.776799. Epub 2017 Apr 5.

A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.

Szteyn K, Rowan MP, Gomez R, Du J, Carlton SM, Jeske NA.

Pain. 2015 Nov;156(11):2364-72. doi: 10.1097/j.pain.0000000000000295.

Divergence in endothelin-1- and bradykinin-activated store-operated calcium entry in afferent sensory neurons.

Szteyn K, Gomez R, Berg KA, Jeske NA.

ASN Neuro. 2015 Apr 13;7(2). pii: 1759091415578714. doi: 10.1177/1759091415578714. Print 2015 Mar-Apr.

Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain.

Weng HJ, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo GC, Wang Y, Geng Y, Zhang J, Guan Y, Akopian AN, Dong X.

β-arrestin-2-biased agonism of delta opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) in primary sensory neurons.

Rowan MP, Szteyn K, Doyle AP, Gomez R, Henry MA, Jeske NA.

Mol Pain. 2014 Aug 1;10:50. doi: 10.1186/1744-8069-10-50.

Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talk.

Rowan MP, Bierbower SM, Eskander MA, Szteyn K, Por ED, Gomez R, Veldhuis N, Bunnett NW, Jeske NA.

PLoS One. 2014 Apr 2;9(4):e93688. doi: 10.1371/journal.pone.0093688. eCollection 2014.

β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.

Por ED, Bierbower SM, Berg KA, Gomez R, Akopian AN, Wetsel WC, Jeske NA.

J Biol Chem. 2012 Oct 26;287(44):37552-63. doi: 10.1074/jbc.M112.391847. Epub 2012 Sep 5.

A-kinase anchoring protein 150 mediates transient receptor potential family V type 1 sensitivity to phosphatidylinositol-4,5-bisphosphate.

Jeske NA, Por ED, Belugin S, Chaudhury S, Berg KA, Akopian AN, Henry MA, Gomez R.

J Neurosci. 2011 Jun 8;31(23):8681-8. doi: 10.1523/JNEUROSCI.0020-11.2011.