Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."
Dr. Nathan Jeske's lab conducts research on signaling mechanisms that mediate inflammatory pain and analgesia. Over 100 million Americans suffer from pain annually, and understanding how this sensation graduates to a chronic state, as well as how to treat it efficaciously, are the primary research goals of the Jeske lab. Research in the Jeske lab focuses on biochemical signaling molecules and pathways unique to pain-sensing neurons in the periphery that can be targeted to reduce pain, increase analgesia, and improve the quality of life for pain patients. Researchers combine molecular, biochemical, pharmacological, physiological, and behavioral studies with opportunities for human clinical expertise to provide comprehensive approaches to some of our most important issues related to pain and analgesia in our current society.
Selected Publications
Brackley AD, Gomez R, Guerrero KA, Akopian AN, Glucksman MJ, Du J, Carlton SM, Jeske NA.
Sci Rep. 2017 May 12;7(1):1842. doi: 10.1038/s41598-017-01999-4.
GRK2 Constitutively Governs Peripheral Delta Opioid Receptor Activity.
Brackley AD, Gomez R, Akopian AN, Henry MA, Jeske NA.
Cell Rep. 2016 Sep 6;16(10):2686-2698. doi: 10.1016/j.celrep.2016.07.084. Epub 2016 Aug 25.
Brackley AD, Sarrami S, Gomez R, Guerrero KA, Jeske NA.
J Biol Chem. 2017 May 26;292(21):8762-8772. doi: 10.1074/jbc.M117.776799. Epub 2017 Apr 5.
Szteyn K, Rowan MP, Gomez R, Du J, Carlton SM, Jeske NA.
Pain. 2015 Nov;156(11):2364-72. doi: 10.1097/j.pain.0000000000000295.
Szteyn K, Gomez R, Berg KA, Jeske NA.
ASN Neuro. 2015 Apr 13;7(2). pii: 1759091415578714. doi: 10.1177/1759091415578714. Print 2015 Mar-Apr.
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain.
Weng HJ, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo GC, Wang Y, Geng Y, Zhang J, Guan Y, Akopian AN, Dong X.
Rowan MP, Szteyn K, Doyle AP, Gomez R, Henry MA, Jeske NA.
Mol Pain. 2014 Aug 1;10:50. doi: 10.1186/1744-8069-10-50.
Rowan MP, Bierbower SM, Eskander MA, Szteyn K, Por ED, Gomez R, Veldhuis N, Bunnett NW, Jeske NA.
PLoS One. 2014 Apr 2;9(4):e93688. doi: 10.1371/journal.pone.0093688. eCollection 2014.
β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel.
Por ED, Bierbower SM, Berg KA, Gomez R, Akopian AN, Wetsel WC, Jeske NA.
J Biol Chem. 2012 Oct 26;287(44):37552-63. doi: 10.1074/jbc.M112.391847. Epub 2012 Sep 5.
Jeske NA, Por ED, Belugin S, Chaudhury S, Berg KA, Akopian AN, Henry MA, Gomez R.
J Neurosci. 2011 Jun 8;31(23):8681-8. doi: 10.1523/JNEUROSCI.0020-11.2011.
Associate Professor
Oral & Maxillofacial Surgery
Ph.D., Pharmacology, University of Texas Health Science Center San Antonio, 2003
B.S., Molecular Biology & Chemistry, Texas Lutheran University, 1999
Email: JESKE@UTHSCSA.EDU
Phone: (210) 567-3466