Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Naomi Sayre, Ph.D.

Naomi sayre labcoat


The laboratory of Dr. Naomi Sayre is interested in the processes that affect repair and recovery after brain damage, with particular emphasis on the role that cholesterol homeostasis plays in these processes. Our research focuses on understanding how cholesterol homeostasis affects two cell types-astrocytes and neural stem cells. As the primary supportive cells in the brain, astrocytes also regulate cholesterol homeostasis, and so have unique potential to affect recovery after brain damage due to trauma or stroke. Neural stem cells travel to the site of brain injury, where they play a role in recovery that has not been fully elucidated.

Selected publications:

Naomi L. Sayre , Mikaela Sifuentes, Deborah Holstein, Sheue-yann Cheng, Xuguang Zhu, James D. Lechleiter. Stimulation of astrocyte fatty acid oxidation by thyroid hormone is protective against ischemic stroke-induced damage. JCBFM in press.

Sayre NL, Rimkunas VM, Graham MJ, Crooke RM, Liscum L. Recovery from liver disease in a Niemann-Pick type C mouse model. J Lipid Res. 2010 Aug;51(8):2372-83. doi: 10.1194/jlr.M007211. Epub 2010 Apr 24.

Sayre NL, Chen Y, Sifuentes M, Stoveken B, Lechleiter JD. Purinergic receptor stimulation decreases ischemic brain damage by energizing astrocyte mitochondria. Adv Neurobiol. 2014;11:121-50. doi: 10.1007/978-3-319-08894-5_7.

Chocron ES, Sayre NL, Holstein D, Saelim N, Ibdah JA, Dong LQ, Zhu X, Cheng SY, Lechleiter JD. The trifunctional protein mediates thyroid hormone receptor-dependent stimulation of mitochondria metabolism. Mol Endocrinol. 2012 Jul;26(7):1117-28. doi: 10.1210/me.2011-1348. Epub 2012 May 8.

Assistant Professor/Research

Department of Neurosurgery


Ph.D., Tufts Sackler School of Graduate Biomedical Sciences, 2009



Phone: (210) 567-9241

Graduate Students

Sadiya Ahmad, CMP (Ph.D)