Dr. Mohan Natarajan has been a research investigator in the field of Molecular and Cell Biology for the past 23 years. His current research interest is focused on cellular/molecular responses and cell signaling upon radiation and or chemo-induced carcinogenesis.
These responses were/are being studied using several cancer models and normal cell types both in vivo and in vitro. He has published more than 64 peer reviewed research articles in highly reputed scientific journals. He has also been invited as plenary speaker or session speaker over 40 national and international academic meetings.
He has developed successful collaborations both nationally and internationally. Through his collaborations, he has expanded his research background into studies involving nitric oxide signaling, breast cancer research and development of animal
models. His expertise in the interrelated fields along with his wealth of research experience and productive collaborations puts him in a unique position to successfully carry out the proposed project.
Aravindan N, Aravindan S, Pandian V, Khan FH, Ramraj SK, Natt P, Natarajan M. 2014. Acquired tumor cell radiation resistance at the treatment site is mediated through radiation-orchestrated intercellular communication. Int J Radiat Oncol Biol Phys. 88 (3):677-85.
Aravindan S, Natarajan M, Ramraj SK, Pandian V, Khan FH, Herman TS, Aravindan N. 2014. Abscopal effect of low-LET γ-radiation mediated through Rel protein signal transduction in a mouse model of nontargeted radiation response. Cancer Gene Ther., 21(2):54-9.
Aravindan S, Natarajan M, Herman TS, Awasthi V and Aravindan N. 2013. Molecular basis of ‘hypoxic’ breast cancer cell radio-sensitization: Phytochemicals converge on radiation induced Rel signaling. Radiation Oncology , 4;8:46.
Aravindan S, Natarajan M, Awasthi V, Herman TS and Aravindan N. 2013 Novel synthetic monoketone EF24 transmute radiotherapy-triggered NF kB dependent TNFa-NF-kB cross-signaling mediated survival advantage, clonal expansion in neuroblastoma. Cancer Res. (In Review).
Yu H, Mohan S, Natarajan M. (2012). Radiation-Triggered NF-κB Activation is Responsible for the Angiogenic Signaling Pathway and Neovascularization for Breast Cancer Cell Proliferation and Growth. Breast Cancer (Auckl). 2012;6:125-35.1.
Risinger AL, Natarajan M, Thomas CR, Mooberry SL. (2011). The taccalonolides, novel microtubule stabilizers, and g-radiation have additive effects on cellular viability. Cancer Lett. 2011 Aug 1;307(1):104-11. Epub 2011 Apr 19.
Veeraraghavan J, Natarajan M, Herman TS & Aravindan N. (2011). Radiation triggered TNF-NF-B cross signaling favors survival advantage in human neuroblastoma. J Biol Chem.(JBC) 2011 Jun 17;286(24):21588-600. Epub 2011 Apr 28.
Veeraraghavan J, Aravindan S, Natarajan M, Awasthi V, Herman TS, Aravindan N. (2011) Neem leaf extract induces radiosensitization in human neuroblastoma xenograft through modulation of apoptotic pathway. Anticancer Research, 31 (1): 161-170.
Veeraraghavan J, Natarajan M, Herman TS, Aravindan N. (2010). Curcumin altered p53-response genes regulate radiosensitivity in p53-mutant Ewing’s sarcoma cells. Anticancer Research, 30, 4007-15.