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Search Program Faculty/Research

Manzoor Bhat, M.S., Ph.D.

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RESEARCH

Intricate molecular interactions between neurons and glial cells form the underlying basis of axonal insulation across species. Mutations in human genes that affect insulation of axons are associated with profound disturbances in normal impulse conduction and significant neurological disabilities. 

Dr. Manzoor Bhat's lab is investigating the genetic and molecular basis of complex and reciprocal interactions between various types of glial cells, which play a key role in axonal insulation, blood-brain barrier formation and axon guidance during Drosophila development. 

Our lab identified Neurexin IV, Contactin and Neuroglian as key molecular components of the glial- and axo-glial septate junctions and showed that these proteins are crucial for the organization and function of the septate junctions. Recent studies in our lab have uncovered additional molecular components which link the midline glial scaffold with midline neurons to bring about commissural axon insulation and proper midline axon guidance.

Selected Publications

Banerjee S, Riordan M, Bhat MA. Genetic aspects of autism spectrum disorders: insights from animal models. Front Cell Neurosci. 2014 Feb 24;8:58.

Green JA, Yang J, Grati M, Kachar B, Bhat MA. Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons. BMC Neurosci. 2013 Sep 6;14:96.

Buttermore ED, Thaxton CL, Bhat MA. Organization and maintenance of molecular domains in myelinated axons. J Neurosci Res. 2013 May;91(5):603-22.

Chen YC, Lin YQ, Banerjee S, Venken K, Li J, Ismat A, Chen K, Duraine L, Bellen HJ, Bhat MA. Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission. J Neurosci. 2012 Nov 7;32(45):16018-30.

Buttermore ED, Piochon C, Wallace ML, Philpot BD, Hansel C, Bhat MA. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development. J Neurosci. 2012 Apr 4;32(14):4724-42.

Professor & Chair

Department of Cellular and Integrative Physiology

Education

Ph.D., Indian Institute of Science, Bangalore, India, and Shiga University Of Medical Science, Shiga, Japan, 1992

M.S., Biochemistry, University of Kashmir, 1986

B.S., Biology, University of Kashmir, 1984

Contact

Email: BHATM@UTHSCSA.EDU

Phone: (210) 567-4327

Research Profile
More info...

Graduate Students

Rosa Mino
IMGP/Physiology (Ph.D.)

Liz Fisher
IMGP/Physiology (Ph.D.)