Dr. LuZhe Sun's laboratory studies molecular mechanisms that regulate cancer development,
growth, invasion, and metastasis, and novel experimental therapeutics for
cancer prevention and treatment using molecular and cellular biology, and
bioinformatics techniques and animal model systems.
Ongoing research projects
include the investigation of how aging, obesity, radiation, and xenoestrogens
may induce a tumorigenic phenotype of mammary stem cells and the investigation
of the roles of transforming growth factor-beta (TGFβ), hedgehog, and androgen
signaling pathways in various types of cancer.
They are developing therapeutic
approaches for the prevention of aging-associated breast cancer and for
abrogating TGFβ, hedgehog, and androgen signaling pathways for the treatment of
aggressive cancers including castration resistant prostate cancer.
Mishra, S., Qin Tai, Xiang Gu, James Schmitz, Ashley Poullard, Roberto J Fajardo, Devalingam Mahalingam, Xiaodong Chen, Xueqiong Zhu, and Lu-Zhe Sun. Estrogen and Estrogen Receptor Alpha Promotes Malignancy and Osteoblastic tumorigenesis of Prostate Cancer. Oncotarget, 6:44388-402, 2015. http://www.ncbi.nlm.nih.gov/pubmed/26575018
Gao, H., Qiaoxiang Dong, Yuanhong Chen, Fuchuang Zhang, Anqi Wu, Yuanshuo Shi, Abhik Bandyopadhyay, Benjamin J. Daniel, Changjiang Huang, and Lu-Zhe Sun. Murine mammary stem/progenitor cell isolation: Different method matters? SpringerPlus, 5:140, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26933638
Liu, Z., Long Wang, Junhua Yang, Abhik Bandyopadhyay, Virginia Kaklamani, Shui Wang, Lu-Zhe Sun. Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells. Oncotarget, 2016. doi: 10.18632. PMID: 27259243
Wu, A., Qiaoxiang Dong, Hui Gao, Yuanshuo Shi, Yuanhong Chen, Fuchuang Zhang, Abhik Bandyopadhyay, Danhan Wang, Karla M. Gorena, Changjiang Huang, Suzette Tardif, Peter W. Nathanielsz, and Lu-Zhe Sun. Characterization of mammary epithelial stem/progenitor cells and their changes with aging in common marmosets. Sci. Rep. 6:32190, 2016. doi: 10.1038/srep32190.
Dong, Q., Hui Gao, Yuanshuo Shi, Fuchuang Zhang, Xiang Gu, Anqi Wu, Danhan Wang, Yuanhong Chen, Abhik Bandyopadhyay, I-Tien Yeh, Benjamin J. Daniel, Yidong Chen, Yi Zou, Vivienne L. Rebel, Christi A. Walter, Jianxin Lu, Changjiang Huang, Lu-Zhe Sun. Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential.Aging, 8(11):2754-2770, 2016. PMCID: PMC5191868
Qin, T., L. Barron, L. Xia, H. Huang, M.M. Villarreal, J. Zwaagstra, C. Collins, J. Yang, C. Zwieb, R. Kodali, C.S. Hinck, S.K. Kim, R.L. Reddick, C. Shu, M.D. O’Connor-McCourt, A.P. Hinck, and Lu-Zhe Sun. A novel highly potent trivalent TGF-β receptor trap inhibits early-stage tumorigenesis and tumor cell invasion in murine Pten-deficient prostate glands. Oncotarget. 2016 Dec 27;7(52):86087-86102. doi: 10.18632/oncotarget.13343.PMCID: PMC5593694
Mishra, S., Janice J. Deng, Pramod S. Gowda, Manjeet K.
Rao, Chun-Lin Lin, Chun Liang Chen, Tim Huang, and Lu-Zhe Sun. Androgen Receptor and MicroRNA-21 axis down-regulates Transforming growth factor beta Receptor II (TGFBR2) expression in Prostate Cancer. Oncogene 33,
Biswas, T, Xiang
Gu, Junhua Yang, Lesley G. Ellies, and Lu-Zhe Sun. Attenuation of TGF-β signaling supports tumor progression of a mesenchymal-like mammary tumor cell line in a syngeneic murine model. Cancer Letters 346:129-138, 2014.
Wang, D., Hui Gao, Abhik Bandyopadhyay, Anqi Wu, I-Tien
Yeh, Yidong Chen, Yi Zou Changjiang Huang, Christi A. Walter, Qiaoxiang Dong, Lu-Zhe
Sun. Pubertal Bisphenol A Exposure Alters Murine Mammary Stem Cell (MaSC) Function Leading to Early Neoplasia in Regenerated Glands. Cancer Prev Res.
7(4): 445-455, 2014.
Mishra, S., Chun-Lin Lin, Tim H-M Huang, Hakim Bouamar,
and Lu-Zhe Sun. MicroRNA-21 inhibits p57Kip2 expression in prostate cancer. Mol. Cancer, 13:212, 2014. http://www.ncbi.nlm.nih.gov/pubmed/25216674