Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Luke Norton, Ph.D.

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Research Interests

My overall goal as a researcher is to combine physiological studies in humans and rodents with cutting-edge molecular and genomics approaches to improve our understanding of the pathogenesis of type 2 diabetes. In particular, I am interested in how novel type 2 diabetes candidate genes influence an individual’s risk for diabetes at the physiological and molecular/genomic level. My lab is also involved in novel studies designed to unravel the mechanism of action of novel and established type 2 diabetes medications in humans, animals and cells. We use a range of modern molecular and physiological tools to approach these questions.

Graduate School Activities

- PHYL 6020: Diabetes Lecture Series, Department of Physiology, UTHSCSA.

- PHAR 5019: Metabolism, Hormones, GI Physiology and Therapeutics, Department of Pharmacology, UTHSCSA

- Graduate Student Mentor (Iriscilla Ayala, UTHSCSA), 2016 – present

- Graduate Student Mentor (Stephen Chen, UTHSCSA) 2013 – present

- Graduate Student Mentor (Lu Zhang, UTHSCSA) 2013 – present

- Graduate Student Mentor (Juan Xiong, UTHSCSA) 2013 – present

- Graduate Student Committee member (Jianbo Wang, UTHSCSA) 2013 – 2014

- Medical Student Research Program mentor 2013 – 2014

Selected Publications

Chen X, Ayala I, Shannon CE, Fourcaudot M, Acharya NK, Jenkinson CP, Heikkinen S, Norton L: The Diabetes Gene and Wnt Pathway Effector TCF7L2 Regulates Adipocyte Development and Function. Diabetes. 2018 (in press)

Norton L, Shannon CE, Fourcaudot M, Hu C, Wang N, Ren W, Song J, Abdul-Ghani M, DeFronzo RA, Ren J, Jia W*: Sodium-glucose (SGLT) and Glucose (GLUT) Transporter Expression in the Kidney of Type 2 Diabetic Subjects. Diabetes Obes Metab. 2017 19(9):1322-1326

ShannonCE, DanieleG, Galindo C, Abdul-Ghani MA, DeFronzo RA, and Norton L: Pioglitazone Inhibits Mitochondrial Pyruvate Metabolism and Glucose Production in Hepatocytes, FEBS J, 2016 (in press)

Norton L, Chen X, Fourcaudot M, DeFronzo RA and Heikkinen S*: The Mechanisms of Genome-Wide Target Gene Regulation by TCF7L2 in Liver Cells, Nucleic Acids Res, 2014 42(22):13646-61 (*corresponding author)

Abdul-Ghani MA, DeFronzo RA and Norton L: A Novel Hypothesis to Explain Why SGLT2 Inhibitors Inhibit only 30-50% of Filtered Glucose Load in Humans Diabetes, 2013 62(10):3324-8, 2013

Norton L, FourcaudotM, Abdul-Ghani MA, WinnierD, MehtaFF, JenkinsonCP and DeFronzo RA: Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism Diabetologia 54(12):3132-42, 2011 (*corresponding author)

Norton L, Parr T, Chokkalingam K, Bardsley RG, Ye H, Bell GI, Pelsers MM, van Loon LJ, Tsintzas K: Calpain-10 mRNA and protein levels in human skeletal muscle: Effect of acute lipid-induced insulin resistance and type 2 diabetes. J Clin Endocrinol Metab 93(3):992-8, 2008

Assistant Professor 

Department of Medicine/Diabetes Division



Phone: (210) 567-0739