Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Linda M. McManus, Ph.D.



Parenchymal tissue injury initiates a rapid cascade of tightly-regulated cellular events designed to repair and/or regenerate the damaged tissue.  These events include a dynamic interplay between cells with regenerative capacity and diverse inflammatory cells; bone marrow-derived cells are critical to these processes.  Current research efforts focus on the molecular and cellular mechanisms which regulate inflammation and the regeneration of murine skeletal muscle.

Selected Publications

McManus LM,Mitchell RN. Editors-in-Chief. Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms, Elsevier, 2014.

Melton DW, LM McManus, JAL Gelfond, PK Shireman. Temporal phenotypic features distinguish polarized macrophages in vitro. Autoimmunity, 48:161-76, 2015.

Wang H, D Melton, L Porter, ZU Sarwar, LM McManus, PK Shireman. Altered macrophage-phenotype transition impairs skeletal muscle regeneration. Am J Pathol, 184:1167-1184, 2014.

Chen Y, Melton DW, Gelfond JA, McManus LM, Shireman PK. MiR-351 transiently increases during muscle regeneration and promotes progenitor cell proliferation and survival upon differentiation. Physiol Genomics. 2012 Nov 1;44(21):1042-51.

Lee LS, Pusek SN, McCormack WT, Helitzer DL, Martina CA, Dozier AM, Ahluwalia JS, Schwartz LS, McManus LM, Reynolds BD, Haynes EN, Rubio DM. Clinical and translational scientist career success: metrics for evaluation. Clin Transl Sci. 2012 Oct;5(5):400-7.


Office of Postdoctoral Affairs


Ph.D., Experimental Pathology, The University of Colorado Medical School, 1978

M.S., Microbiology, The University of Houston, 1973

B.A., Microbiology, The University of Texas, 1970



Phone: 210-567-4071

Research Profile
More Info...