Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Keith A. Krolick, Ph.D.

Krolick photo

RESEARCH

Autoimmunity (immunity against one's self), the cause of a variety of health problems, has been the central theme my interests. For nearly thirty years, my laboratory used numerous strategies for studying one particular autoimmune disease, the neuromuscular disorder myasthenia gravis (MG). 

We have discovered that muscle shares the ability to produce a variety of important factors and receptors for those factors that are also produced by the immune system. This allows 2-way communication between muscle and the immune system, and dictates the severity of eventually impaired muscle function and the symptoms that follow. I have recently closed my lab but continue to pursue my interests in immunology via contributions to the educational missions of the university.

Selected Publications

Krolick KA. Muscle-derived nitric oxide synthase expression, differences associated with muscle fiber-type, and disease susceptibility in a rat model of myasthenia gravis.Clin Immunol. 2006 Dec;121(3):286-93. Clin Immunol. 2006 Dec;121(3):286-93.

Garcia YR, Krolick KA. Short-circuiting autoimmune disease by target-tissue-derived nitric oxide. Clin Immunol. 2004 Oct;113(1):74-80.

Garcia YR, Pothitakis JC, Krolick KA. Myocyte production of nitric oxide in response to AChR-reactive antibodies in two inbred rat strains may influence disease outcome in experimental myasthenia gravis. Clin Immunol. 2003 Feb;106(2):116-26.

Reyes-Reyna S, Stegall T, Krolick KA. Muscle responds to an antibody reactive with the acetylcholine receptor by up-regulating monocyte chemoattractant protein 1: a chemokine with the potential to influence the severity and course of experimental myasthenia gravis. J Immunol. 2002 Aug 1;169(3):1579-86.

Stegall T, Krolick KA. Myocytes respond in vivo to an antibody reactive with the acetylcholine receptor by upregulating interleukin-15: an interferon-gamma activator with the potential to influence the severity and course of experimental myasthenia gravis. J Neuroimmunol. 2001 Oct 1;119(2):377-86.

Professor
Microbiology, Immunology, and Molecular Genetics

Education

Ph.D., Immunology, University of California Los Angeles, 1977

B.S., Microbiology, University of Illinois at Urbana, 1973

Contact

Email: KROLICK@UTHSCSA.EDU

Phone: (210) 567-3968


Research Profile
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