Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Keith A. Krolick, Ph.D.

Krolick photo

RESEARCH

Dr. Krolick’s formal training was in Microbiology and Immunology. As a tenured member of the UT Health San Antonio graduate faculty, he performed continuously funded research in areas of immunology (particular emphasis on autoimmune disease) for over 30 years while training numerous doctoral students.

During those years, Dr. Krolick contributed to a new phase in our understanding of cellular and molecular mechanisms that result in immune responsiveness and our ability to protect ourselves from infectious diseases… the network of cells and soluble factors necessary for the desired collaborative intercellular interactions. However, Dr. Krolick’s interests led him to studies involving the system of carefully placed biological “filters” designed to avoid autoimmune diseases by eliminating self-reactive lymphocytes. Thus, autoimmunity (immunity against one’s self), the cause of a variety of health problems, has been the central theme his interests. His laboratory used numerous strategies to study one particular autoimmune disease, myasthenia gravis (MG).

Dr. Krolick has recently closed his lab and has shifted his emphasis from laboratory research to the educational and administrative missions of the Graduate School and the University. He is the Program Director for the Integrated Biomedical Sciences (IBMS) Graduate Program, the largest program in of the Graduate School of Biomedical Sciences, as well as the head of the microbiology & immunology component of the IBMS Graduate Program. Dr. Krolick is also the Associate Director of our Master of Science in Immunology & Infection program. To remain engaged with the students and his passion for teaching, he teaches in all five schools that make up UT Health San Antonio, in both basic science and pre-clinical science courses for PhD and MS students, and for medical, dental, and nursing students. He also serves as the director of several graduate level and pre-clinical courses. Dr. Krolick was elected as a member of the UT Health San Antonio Academy of Master Teachers, and as a University of Texas System Distinguished Teaching Professor. 

Selected Publications

Krolick KA. Muscle-derived nitric oxide synthase expression, differences associated with muscle fiber-type, and disease susceptibility in a rat model of myasthenia gravis.Clin Immunol. 2006 Dec;121(3):286-93. Clin Immunol. 2006 Dec;121(3):286-93.

Garcia YR, Krolick KA. Short-circuiting autoimmune disease by target-tissue-derived nitric oxide. Clin Immunol. 2004 Oct;113(1):74-80.

Garcia YR, Pothitakis JC, Krolick KA. Myocyte production of nitric oxide in response to AChR-reactive antibodies in two inbred rat strains may influence disease outcome in experimental myasthenia gravis. Clin Immunol. 2003 Feb;106(2):116-26.

Reyes-Reyna S, Stegall T, Krolick KA. Muscle responds to an antibody reactive with the acetylcholine receptor by up-regulating monocyte chemoattractant protein 1: a chemokine with the potential to influence the severity and course of experimental myasthenia gravis. J Immunol. 2002 Aug 1;169(3):1579-86.

Stegall T, Krolick KA. Myocytes respond in vivo to an antibody reactive with the acetylcholine receptor by upregulating interleukin-15: an interferon-gamma activator with the potential to influence the severity and course of experimental myasthenia gravis. J Neuroimmunol. 2001 Oct 1;119(2):377-86.

Professor
Microbiology, Immunology, and Molecular Genetics

Education

Ph.D., Immunology, University of California Los Angeles, 1977

B.S., Microbiology, University of Illinois at Urbana, 1973

Contact

Email: KROLICK@UTHSCSA.EDU

Phone: (210) 567-3968


Research Profile
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