Dr. José Cavazos's lab studies activity-dependent plasticity in the hippocampal formation in the developing, adult, and aged brain using a variety of experimental models of epilepsy, seizures, and epileptogenesis. Previous studies from our laboratory have shown that repeated seizures induce progressive neuronal death and axon sprouting that permanently alter the hippocampal circuitry lending it more susceptible to additional seizures and memory dysfunction.
We currently are investigating the molecular mechanisms that link the synchronous neuronal hyperexcitability with these morphological events. We investigate the features of seizure-induced axon sprouting in other limbic circuitries using anatomical tracing techniques, and their electrophysiological consequences in the neuronal excitability of the abnormally connected circuitry using brain slices and in-vivo using electrophysiological and neuroimaging techniques. We also have several ongoing clinical projects about people with epilepsy, particularly, focusing on the utilization of anticonvulsants.
Lie OV, Papanastassiou AM, Cavazos
JE, Szabó CÁ. Influence of intracranial electrode density and spatial configuration on interictal spike localization: a case study. J Clin
Neurophysiol. 2015 Jan 9.
Wang Z, Li X, Powers A, Cavazos
JE. Outcomes associated with switching from monotherapy to adjunctive therapy for patients with partial onset seizures. Expert Rev Pharmacoecon Outcomes Res. 2015 Apr;15(2):349-55. doi: 10.1586/14737167.2015.989217. Epub
2014 Dec 4.
Barron DS, Fox PT, Pardoe H,
Lancaster J, Price LR, Blackmon K, Berry K, Cavazos JE, Kuzniecky R,
Devinsky O, Thesen T. Thalamic functional connectivity predicts seizure laterality in individual TLE patients: application of a biomarker development strategy. Neuroimage Clin. 2014 Aug 7;7:273-80. doi:
10.1016/j.nicl.2014.08.002. eCollection 2015.
Margolis JM, Chu BC, Wang ZJ,
Copher R, Cavazos JE. Effectiveness of antiepileptic drug combination therapy for partial-onset seizures based on mechanisms of action. JAMA Neurol. 2014 Aug;71(8):985-93. doi:
Lie OV, Cavazos JE. Responsive neurostimulation in epilepsy therapy: some answers, lingering questions. Epilepsy Behav. 2014 May;34:25-8. doi:
10.1016/j.yebeh.2014.02.014. Epub 2014 Mar 25. No abstract available.
Victorson D, Cavazos JE, Holmes GL, Reder AT, Wojna V, Nowinski C, Miller D, Buono S, Mueller A, Moy C, Cella D. Validity of the Neurology Quality-of-Life (Neuro-QoL) measurement system in adult epilepsy. Epilepsy Behav. 2014 Feb;31:77-84.
Tolstykh GP, Cavazos JE. Potential mechanisms of sudden unexpected death in epilepsy. Epilepsy Behav. 2013 Mar;26(3):410-4.
Cella D, Lai JS, Nowinski CJ, Victorson D, Peterman A, Miller D, Bethoux
F, Heinemann A, Rubin S, Cavazos JE, Reder AT, Sufit R, Simuni T,
Holmes GL, Siderowf A, Wojna V, Bode R, McKinney N, Podrabsky T, Wortman
K, Choi S, Gershon R, Rothrock N, Moy C. Neuro-QOL: brief measures of health-related quality of life for clinical research in neurology. Neurology. 2012 Jun 5;78(23):1860-7.
Zhang K, Tolstykh GP, Sanchez RM, Cavazos JE. Chronic Cellular Hyperexcitability in Elderly Epileptic Rats with Spontaneous Seizures Induced by Kainic Acid Status Epilepticus while Young Adults. Aging Dis. 2011 Aug;2(4):332-8.