Dr. Jian Ling is an Institute Scientist of Department of Pharmaceuticals and Bioengineering at the Southwest Research Institute. Dr. Ling has been involved in biomedical research and medical device development for over 25 years, and has led the development of varieties of biomedical devices and researches. He was the PI for the development of polymer-based nano-encapsulation for protein delivery, and lipid-encapsulated small molecules for control release. He led the development of composite tissue engineering materials and bioreactors for bone, meniscus, and vascular regeneration. He also led the development of an organ perfusion system for long-term organ preservation, and an NIH funded project to investigate an engineered 3D bone marrow environment for stem cell expansion. Dr. Ling was also the project manager for the development of a fiber optics-based Raman spectroscopy for clinical diagnosis, and the use of multi-color immunofluorescence imaging and flow cytometry for cancer diagnosis.
Dr. Ling’s research interests are in the development of biomaterials, bioreactors, and stem cell applications for wound healing and regenerative medicine. His interests are also in the application of nano-encapsulation for protein and RNA/DNA delivery and controlled release. Dr. Ling is familiar with the process to translate technology to medical products under the ISO 13485 quality system that is compliant with the FDA regulation 21 CFR Part 820.
Selected Publications and Patents
Antebi B, Zhang ZL, Wang Y, Lu ZD, Chen XD, Ling, J. Stromal cell-derived extracellular matrix promotes the proliferation and retains the osteogenic differentiation capacity of mesenchymal stem cells on three-dimensional scaffolds. Tissue Engineering: Part C, Methods, 21(2), p171-81, 2015.
Antebi B, Cheng XG, Harris JN, Gower LB, Chen XD, Ling J. “Biomimetic collagen-hydroxyapatite composite fabricated via a novel perfusion-flow mineralization technique”, Tissue Engineering: Part C, Vol 19(7), p 487-496, 2013.
Sun Y., Li W., Lu Z., Chen R., Ling J., Ran Q., Jilka R.L., Chen X.D., “Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix”, FASEB J., Vol. 25, p 1474-1485, 2011.
Rath A.L., Bonewald L.F., Ling J., Jiang JX, Van Dyke M.E., Nicolella D.P., “Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow”, Journal of Biomechanics, Vol. 43, No. 8, p. 1560-4, 2010.
Lai Y.L., Sun Y., Skinner C.M., Son E.L., Lu Z.D., Tuan R.S., Jilka R.L., Ling J., and Chen X.Dong, “Reconstitution of Marrow-derived Extracellular Matrix Ex Vivo: a Robust Culture System for Expanding Large-scale Highly Functional Human Mesenchymal Stem Cells”, Stem Cells and Development, Vol. 19, No. 7, p. 1095-107, 2010.
Ling J., Chen X.D. “Bone marrow stromal cell-derived extracellular matrix promotes mesenchymal stem cell motility”, International Society for Analytical Cytology XXIV International Congress, Budapest, Hungary, May, 2008.
U.S. Patent 9,456,893, 2016: “Engineered Tissue Implants and Methods of Use Thereof”.
U.S. Patent 9,044,530, 2015: “Fabrication of bone regeneration scaffolds and bone filler material using a perfusion flow system”
U.S. Patent 8,815,594, 2014: “Hybrid Tissue Scaffold for Tissue Engineering”