Dr. Janice Jianhong Deng is interested in:
- Restoration of mitochondrial dysfunction:
We are exploring approaches to repair mitochondrial defects in cell models carrying various types of mitochondrial mutations.
- Mitochondrial quality control:
We are in the process to identify and characterize protein factors involved in various stages of mitochondrial quality control.
- Role of respiratory complex dynamics in neuronal system:
We are generating various animal models of neuronal specific alterations in respiratory complex dynamics and investigating the consequences.
Vartak R, Deng J, Fang H, Bai Y. (2015) Redefining the roles of mitochondrial DNA-encoded subunits in respiratory Complex I assembly. Biochim Biophys Acta. 2015 Jul;1852(7):1531-9.
Mishra S, Deng JJ, Gowda PS, Rao MK, Lin CL, Chen CL, Huang T, Sun LZ. (2014) Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer. Oncogene. 2014 Jul 31;33(31):4097-106.
Gowda PS, Deng JD, Mishra S, Bandyopadhyay A, Liang S, Lin S, Mahalingam D, Sun LZ. (2013) Inhibition of hedgehog and androgen receptor signaling pathways produced synergistic suppression of castration-resistant prostate cancer progression. Mol Cancer Res. 2013 Nov;11(11):1448-61.
Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y. (2011) Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. Hum Mol Genet. 2011 Dec 1;20(23):4605-16.
Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. (2010) NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem. 2010 Mar 5;285(10):7417-29.