Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Janice Jianhong Deng, M.D.

Deng

RESEARCH

Dr. Janice Jianhong Deng is interested in: 

- Restoration of mitochondrial dysfunction:
We are exploring approaches to repair mitochondrial defects in cell models carrying various types of mitochondrial mutations.

- Mitochondrial quality control:
We are in the process to identify and characterize protein factors involved in various stages of mitochondrial quality control.

- Role of respiratory complex dynamics in neuronal system:
We are generating various animal models of neuronal specific alterations in respiratory complex dynamics and investigating the consequences.

Selected Publications:

Vartak R, Deng J, Fang H, Bai Y. (2015) Redefining the roles of mitochondrial DNA-encoded subunits in respiratory Complex I assembly. Biochim Biophys Acta. 2015 Jul;1852(7):1531-9.

Mishra S, Deng JJ, Gowda PS, Rao MK, Lin CL, Chen CL, Huang T, Sun LZ. (2014) Androgen receptor and microRNA-21 axis downregulates transforming growth factor beta receptor II (TGFBR2) expression in prostate cancer. Oncogene. 2014 Jul 31;33(31):4097-106.

Gowda PS, Deng JD, Mishra S, Bandyopadhyay A, Liang S, Lin S, Mahalingam D, Sun LZ. (2013) Inhibition of hedgehog and androgen receptor signaling pathways produced synergistic suppression of castration-resistant prostate cancer progression. Mol Cancer Res. 2013 Nov;11(11):1448-61.

Sharma LK, Fang H, Liu J, Vartak R, Deng J, Bai Y. (2011) Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. Hum Mol Genet. 2011 Dec 1;20(23):4605-16.

Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. (2010) NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem. 2010 Mar 5;285(10):7417-29.

Instructor/Research

Education

M.D., Medical Science, Xian Medical College, 1983

Contact

Phone: 210-567-1501

Email: deng@uthscsa.edu