Dr. Lechleiter's laboratory is interested in the molecular and cellular mechanisms of
neuroprotection that occur in response to ischemic stress, acute brain
injury and aging. Most strategies to reduce, slow and repair the
severity of brain injuries have focused almost exclusively on neurons.
We have focused our research on the potential of astrocytes as a novel
theurapeutic avenue for brain treatment.
Astrocytes are known to play a
crucial role in supporting and protecting neuronal function and in
modulating brain energy metabolism. A therapeutic strategy that
increases energy production is inherently robust, since the number of
potential neuroprotective processes that benefit are significantly
higher than a single molecular target.