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Search Program Faculty/Research

James D. Stockand, Ph.D.

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RESEARCH

Research in the Stockand laboratory focuses on ion channels and ion transport. We are particularly interested in the proteins involved in controlling ion movement into neurons and epithelial cells. The prior is important to excitability and how central neurons signal to each other and how peripheral neurons allow us to sense our environment.  Ion channels in the kidney play a central role in controlling blood pressure as they set circulatory volume and the water and electrolyte content of plasma. We focus on understanding biologically important mechanisms that affect physiology. The lab has a long publication history on the mechanisms of regulation, structure-function relations and physiologic function of Deg/ENaC ion channels, in which we have employed electrophysiology, live-cell optical/fluorescence imaging, biochemical and molecular biological approaches, as well as contemporary molecular genetics and assessment of renal function, blood pressure and behavior in live animals.

Selected Publications

Mironova, E., Bugaj, V., Roos, K.P., Kohan, D.E. andStockand, J.D.

Aldosterone-independent regulation of ENaC by vasopressin in adrenalectomized mice. PNAS. 109:10095-10100, 2012. PMID: 22665796

Stockand, J.D. The role of the epithelial Na+ channel (ENaC) in high AVP but low aldosterone states. Frontiers in Physiology - Renal and Epithelial Physiology. 3:1-5, 2012.

Bugaj, V., Sansom, S.C., Wen, D., Hatcher, L.I., Stockand, J.D. and Mironova, E.Flow-sensitive potassium-coupled ATP secretion modulates ENaC activity in the distal nephron. JBC. 287:38552-38558, 2012. PMID: 23002235

Boiko, N., Kucher, V., Stockand, J.D. and Eaton, B.A. Pickpocket1 is an ionotropic molecular sensory transducer. JBC. 287:39878-39886, 2012. PMID: 23033486

Boiko, N., Kucher, V., Eaton, B.A. and Stockand, J.D. Inhibition of Neuronal Degenerin/epithelial Na+channels by the Multiple Sclerosis Drug 4-Aminopyridine.JBC. 288:9418-9427, 2013. PMID: 23404498

 Boiko, N., Kucher V., Wang, B. and Stockand, J.D. Restrictive Expression of Acid-Sensing Ion Channel 5 (Asic5) in Unipolar Brush Cells of the Vestibulocerebellum. Plos One. 9:e91326, 2014. PMID: 24663811

Mironova, E., Chen, Y., Pao, A.C., Roos, K.P., Kohan, D.E., Bugaj, V. and Stockand, J.D. Activation of ENaC by AVP contributes to urinary concentrating mechanism and dilution of plasma. Am. J. Physiol. 308:F237-F243, 2015. PMID: 25391898

Mironova, E., Boiko, N., Bugaj, V., Kucher, V. and Stockand, J.D. Regulation of Na+ excretion and arterial blood pressure by purinergic signaling intrinsic to the distal nephron: consequences and mechanisms. Acta Physiologica. 213:213-221, 2015. PMID: 25154328.

Akitake, B., Ren, Q., Boiko, N., Ni, J., Sokabe, T., Stockand, J.D., Eaton, B.A. and Montell, C. Coordination and Fine Motor Control Depends on Drosophila TRPg. Nature Comm. 6:7288, 2015. PMID: 26028119.

Boiko, N., Medrano, G., Montano, E., Jiang, N., Williams, C.R., Madungwe, N.B., Bopassa, J.C., Kim, C.C.,Parrish, J.Z., Hargreaves, K.M., Stockand, J.D.1 and Benjamin A. Eaton1. 1These authors contributed equally. TrpA1 activation in peripheral sensory neurons underlies the ionic basis of pain hypersensitivity in response to vinca alkaloids. Plos One. 12(10):e0186888, 2017.

Professor, Department of Cellular and Integrative Physiology

Director, Pathobiology of Occlusive Vascular Disease Fellowship Program

Discipline Coordinator, Physiology, UME CIRCLE Curriculum

Education

Ph.D., Physiology/Integrative
The University of Texas Health Science Center at Houston, 1996

B.S., Biochemistry and Genetics
Texas A&M University, 1991

Contact

Email: STOCKAND@UTHSCSA.EDU

Phone: 210-567-4332

Research Profile
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