Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Hai-Chao Han, Ph.D.

Han-1-web cropped

RESEARCH

Dr. Han is a professor & department chair in the Department of Mechanical Engineering at The University of Texas at San Antonio. He is interested in bioengineering, cardiovascular biomechanics, left ventricular remodeling, vascular remodeling, artery buckling and tortuosity, and vascular disease.

Selected Publications

1.Halaney DL, Sanyal A, Nafissi NA, Escobedo D, Goros M, Michalek J, Acevedo PJ, Pérez W, Escobar GP, Feldman MD, Han HC (2017). The importance of trabeculae carneae for left ventricular diastolic compliance: improvement in compliance with trabecular cutting. J Biomech Eng. 139(3), 031012.

2.Yang H, Fortier A, Horne K, Mohammad A, Banerjee S, Han HC (2017), Investigation of Stent Implant Mechanics Using Linear Analytical and Computational Approach. Cardiovascular Eng Tech. 8(1):81-90.

3.Garcia JR, Sanyal A, Fatemifar F, Mottahedi M, Han HC (2017). Twist buckling of veins under torsional loading. J Biomech 58: 123-130.

4.Wang GL, Wang LY, Yang SX, Zhang P, Chen XH, Yao QP, Gong XB, Qi YX, Jiang ZL, Han HC (2016). Arterial wall remodeling under sustained axial twisting in rat. J Biomech 60:124-133.

5.Chesnutt JKW, Han HC (2016). Computational simulation of platelet interactions in the initiation of stent thrombosis due to stent malapposition. Phys Biol 13(1):016001.

6.Yabluchanskiy A, Ma Y, DeLeon-Pennell KY, Altara R, Halade GV, Voorhees AP, Nguyen NT, Jin YF, Winniford MD, Hall ME, Han HC, Lindsey ML (2016). Myocardial Infarction Superimposed on Aging: MMP-9 Deletion Promotes M2 Macrophage Polarization. J Gerontol A Biol Sci Med Sci. 71(4):475-83.

7.Mottahedi M, Han HC (2016). Artery buckling analysis using two layered model with collagen dispersion. J Mech Behavior Biomed Mat 60: 515–524.

8.Xiao Y, Liu Q, Han HC (2016). Buckling reduces eNOS production and stimulates extracellular matrix remodeling in arteries in ex vivo organ culture. Ann Biomed Eng. 44(9):2840-50.

9.Han HC, Liu Q, Jiang ZL (2016). Mechanical Behavior and Wall Remodeling of Blood Vessels under Axial Twist (Invited review). J Med Biomech, 31(4):319-326.

10.Alagarsamy K, Fortier A, Kumar N, Mohammad A, Banerjee S, Han HC, Mishra RS (2016). Computational modeling of stent implant procedure and comparison of different stent materials. J Biomed Eng Res. 1: 101.

11.FatemiFar F, Han HC (2016). Effect of axial stretch on lumen collapse of arteries. J Biomech Eng. 138(12), 124503 (Nov 03, 2016).

12.Alagarsamy K, Fortier A, Komarasamy M, Mishra R, Mohammad A, Banerjee S, Han HC (2017). Mechanical properties of High Entropy Alloy Al0.1CoCrFeNi for Peripheral Vascular Stent Application. Cardiovasc Eng & Tech. 7(4): 448-454.

13.Chesnutt JKW, Han HC (2015). Simulation of the microscopic process during initiation of stent thrombosis. Comput Biol Med 56:182-191. Jan 1, 2015.

14.Sanyal A, Han HC (2015). Artery buckling affects the mechanical stress in atherosclerotic plaques. Biomed Eng Online 14(Suppl 1): S4.

15.Khalafvand SS, Han HC (2015), Stability of carotid artery under steady state and pulsatile blood flow: A fluid-structure interaction study. ASME J Biomech Eng. 137(6): 061007.

16.Luetkemeyer CM, James RH, Devarakonda ST, Le VP, Liu Q, Han HC, Wagenseil J (2015). Critical buckling pressures in mouse arteries with altered elastic fibers. J Mech Behav Biomed Mater 46: 69-82.

17.Voorhees AP, DeLeon-Pennell KY, Ma Y, Halade GV, Yabluchanskiy A, Iyer RP, Flynn E, Cates VA, Lindsey, ML, and Han, HC (2015). Building a Better Infarct: Modulation of Collagen Cross-linking to Increase Infarct Stiffness and Reduce Left Ventricular Dilation post-Myocardial Infarction. J Mol Cell Cardiol 85:229-239.

18.Wang G, Xiao Y, Voorhees AP, Qi YX, Jiang Z, Han HC (2015). Artery remodeling under axial twist in three days organ culture. Ann Biomed Eng 43(8): 1738-47.

19.Voorhees AP. Han HC (2015). Biomechanics of Cardiac Function. (Invited review). Comprehensive Physiol. 5:1623–1644. Oct. 2015.

20.Huang K, Yan ZQ, Zhao D, Chen SG, Gao LZ, Zhang P, Shen BR, Han HC, Qi YX, Jiang ZL (2015). SIRT1 and FOXO mediate contractile differentiation of vascular smooth muscle cells under cyclic stretch. Cell Physiol Biochem. 37(5): 1817-1829.

21.Qi N, Gao H, Ogden RW, Holzapfel GA, Han HC, Luo XY (2015). Investigation of the optimal collagen fibre orientation in human iliac arteries.J Mech Behavior Biomed Mat 52: 108-119.

22.Grimes KM, Voorhees A, Chiao YA, Han HC, Lindsey ML, Buffenstein R (2014). Cardiac function of the naked mole-rat: ecophysiological responses to working underground. Am J Physiol. - Heart Circ Physiol. 306(5): H730-H737.

23.Voorhees A. Han HC (2014). A model to determine the effect of collagen fiber alignment on heart function post myocardial infarction. J Theoretical Biol Model 11:6 (1-19).

24.Yabluchanskiy A, Ma Y, Chiao YA, Lopez EF, Voorhees AP, Toba H, Hall ME, Han HC, Lindsey ML, Jin YF (2014). Cardiac aging is initiated by matrix metalloproteinase-9 mediated endothelial dysfunction. Am J Physiol. -Heart Circ Physiol. 306(10): H1398-H1407.

25.Zhang J*, Liu Q*, Han HC (2014). An in vivo animal model of artery buckling for studying wall remodeling. Ann Biomed Eng 42(8): 1658-1667.

26.Liu Q, Wen Q, Mottahedi M, Han HC (2014). Artery buckling analysis using four-fiber wall model. J Biomech. 47(11): 2790-2796.

27.Xiao Y, Hayman D, Khalafvand SS, Lindsey ML, Han HC (2014). Artery buckling stimulates cell proliferation and NF-κB signaling. Am J Physiol. -Heart Circ Physiol. 307(4): H542-H551.

28.Lee AY*, Sanyal A*. Shadfan R, Xiao Y, Han HC (2014). Mechanical instability of normal and aneurismal arteries. J Biomech 47(16): 3868-3875.

29.Liu Q, Han HC (2013). Mechanical buckling of arterioles in collateral development. J Theor Biol, 316: 42-48.

30.Hayman DM, Zhang J, Liu Q, Xiao Y, Han HC (2013). Smooth muscle contraction increases the critical buckling pressure of arteries. J Biomech 46(4):841-4; 2013.

31.Ma Y, Halade GV, Zhang J, Ramirez TA, Levin D, Voorhees A, Jin YF, Han HC, Manicone AM, and Lindsey ML (2013). Matrix metalloproteinase-28 deletion exacerbates cardiac dysfunction and rupture following myocardial infarction in mice by inhibiting M2 macrophage activation. Circ Res 112(4): 675-688.

32.Han HC, Chesnutt JKW, Garcia JR, Liu Q, Wen Q (2013). Artery buckling: new phenotypes, models, and applications. (Invited review) Ann Biomed Eng 41(7):1399-1410.

33.Garcia JR, Lamm SD, Han HC (2013). Twist buckling behavior of arteries. Biomech Model Mechanobiol 12(5): 915-927, Oct 2013.

34.Chesnutt JKW, Han HC (2013). Platelet size and density affect shear-induced thrombosis formation in tortuous arterioles. Phys Biol 10(5):056003.

35.Chesnutt JKW, Han HC (2013). Effect of red blood cells on platelet activation and thrombus formation in tortuous arterioles. Frontiers Bioeng Biotech. 1:18 (1-12).

Professor & Department Chair 

Zachry Endowed Chair Department of Mechanical Engineering 

The University of Texas at San Antonio (UTSA) Professor

Ph.D. Program in Biomedical Engineering 

Fellow of AHA, AIMBE, and ASME

Education

Ph.D., Xi'an Jiaotong University, China, 1991 

Jointly trained at University of California at San Diego, 1989-1991 

M.S., Xi'an Jiaotong University, China, 1987

B.S., Xi'an Jiaotong University, China, 1984

Contact

Email: hai-chao.han@utsa.edu

Phone: 210-458-4952