Research in Dr. Greg Collins’ laboratory is broadly aimed at
understanding the determinants of drug-taking and drug-seeking behaviors.
Accordingly, we utilize a variety of behavioral and physiological procedures
including intravenous self-administration and implantable telemetry combined
with quantitative analyses to (1) identify factors that alter vulnerability to
drug abuse and relapse; (2) characterize the abuse-related and toxic effects of
drugs of abuse; and (3) develop and test novel pharmacotherapies for the
treatment of substance use disorders.
Current research is focused on characterizing the
abuse-related and toxic effects of synthetic cathinones (e.g., MDPV, α-PVP, and
methylone), an emerging class of abused drugs commonly referred to as “bath
salts.” Although their composition can vary greatly, “bath salts” are most
often mixtures of multiple pharmacologically active compounds.
studies utilize highly quantitative behavioral and pharmacological procedures to
determining whether the reinforcing, discriminative stimulus, and toxic
(behavioral and cardiovascular) effects of synthetic cathinones are enhanced
when administered in combination with common “bath salts” constituents (e.g., other
cathinones or caffeine).
Gannon BM, Galindo KI, Mesmin MP, Sulima A, Rice KC, Collins GT. (2017) Relative reinforcing effects of second-generation synthetic cathinones: acquisition of self-administration and fixed ratio dose-response curves in rats. Neuropharmacology. (In Press) [PMID: 28811192]
Gannon BM, Galindo KI, Mesmin MP, Rice KC, Collins GT. (2017) Reinforcing effects of binary mixtures of common bath salts constituents: studies with 3,4-methylenedioxypyrovalerone (MDPV), 3,4-methylenedioxymethcathinone (methylone), and caffeine in rats. Neuropsychopharmacology. (In Press) [PMID: 28677665]
Gannon BM, Galindo KI, Rice KC, Collins GT. (2017) Individual differences in the relative reinforcing effects of 3,4-methylenedioxypyrovalerone (MDPV) under fixed and progressive ratio schedules of reinforcement in rats. Journal of Pharmacology and Experimental Therapeutics. 361(1):181-189. [PMID: 28179474]
Collins GT, Gerak LR, Javors MA, and France CP. (2016) Lorcaserin reduces the discriminative stimulus and reinforcing effects of cocaine in rhesus monkeys. Journal of Pharmacology and Experimental Therapeutics. 356(1):85-95. [PMID: 26534942]
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