Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Georgianna Gould, Ph.D.

Gouldgg-physiology-resfac-1

RESEARCH

Social behavior, its serotonergic underpinnings and developmental disruption of the social brain in autism, schizophrenia, and other psychiatric disorders are the focus of Dr. Georgianna Gould’s research. 

Her goals are to aid in developing improved treatment interventions for sociability deficits, and to identify common temporal and physiological vulnerabilities to environmental risk factors for autism. 

Her approach combines a battery of drug-treatment sensitive translational behavior tests of sociability, cognition and emotionality with in vitro measures of monoamine receptor and transporter density and function, and circulating levels of hormones such as oxytocin and corticosterone by immunoassay. 

Her postdoctoral studies in the laboratory of Dr. Alan Frazer (Pharmacology) focused on the role of transporter function in antidepressant action and on behavioral depression models in rats. 

Dr. Lynette Daws is her faculty sponsor, and together they investigate auxiliary monoamine transporters as promising pharmaceutical targets.  

Selected Publications

Zhang WQ, Smolik CM, Barba-Escobedo PA, Gamez M, Sanchez JJ, Javors MA, Daws LC, Gould GG. 2015. Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strains. Neuropharmacology. 90:1-8.

Gould GG, Burke TF, Osorio MD, Smolik CM, Zhang WQ, Onaivi ES, Gu TT, DeSilva MN, Hensler JG. 2014. Enhanced novelty-induced corticosterone spike and upregulated serotonin 5-HT1A and cannabinoid CB1 receptors in adolescent BTBR mice. Psychoneuroendocrinology. 39:158-69.

Barba-Escobedo PA, Gould GG. 2012. Visual social preferences of lone zebrafish in a novel environment: strain and anxiolytic effects. Genes Brain Behav. 11:366-73.

Gould GG, Seillier A, Weiss G, Giuffrida A, Burke TF, Hensler JG, Rock C, Tristan A, McMahon LR, Salazar A, O'Connor JC, Satsangi N, Satsangi RK, Gu TT, Treat K, Smolik C, Schultz ST. 2012. Acetaminophen differentially enhances social behavior and cortical cannabinoid levels in inbred mice. Prog Neuropsychopharmacol Biol Psychiatry. 238:260-9.

Daws LC, Gould GG. 2011. Ontogeny and regulation of the serotonin transporter: providing insights into human disorders. Pharmacol Ther. 131:61-79.

Lau BY, Mathur P, Gould GG, Guo S. 2011. Identification of a brain center whose activity discriminates a choice behavior in zebrafish. Proc Natl Acad Sci U S A. 108:2581-6. 

Associate Professor, Research, Department of Cellular and Integrative Physiology

Education

Ph.D., Ecology, Evolution & Behavior, Syracuse University, 2001

M.S., Zoology, Texas A&M University, 1994

B.S., Biology, Cornell University, 1992

Contact

Email: gouldg@uthscsa.edu

Phone: (210) 567-6541