I have a long-standing interest in familial cancer and the application of cancer predisposition to cancer risk assessment, early detection, and prevention in children and adults. Our CPRIT-funded Prevention Project has established infrastructure for comprehensive cancer genetic risk assessment, genetic counseling and testing at sites throughout San Antonio as well as the Rio Grande Valley, and the western border regions of Texas. Within this CPRIT funded project, we also have developed a curriculum specific for genetic risk assessment based on a framework of the ACGME competencies.
I have laboratory and clinical interest and background in the biology of pediatric liver tumors as well as other rare tumors. My group previously described the first recurring translocation in hepatoblastoma and also described the spectrum of APC mutations in hepatoblastoma. Recently I was the Lead P.I. for our CPRIT funded Multi-Investigator project, "Genetics and Biology of Liver Tumorigenesis in Children" with collaborating investigators at Baylor College of Medicine and UT Southwestern. This project defined the genetic landscape of hepatoblastoma and also identified a panel of stem cell markers as well as NFE2L2 mutation as prognostic markers in hepatoblastoma.
My group has also begun a study of predisposition factors for leukemia that are unique to the Hispanic children of South Texas.
I have several administrative roles in research including co-Leader of the Population Science and Prevention Program within the UT Health Cancer Center, Division Director Pediatric Hematology-oncology and Interim Chair, Department of Pediatrics.
Kalish JM, Doros L, Hellman L, Hennekam RCM, Kuiper R, Maher E, Nichols KE, Plon SE, Porter CC, Rednam S, Schultz KAP, States LJ, Tomlinson GE, Zelley K,. Druley TE. Surveillance recommendations for children with overgrowth syndromes and predisposition to Wilms tumors and hepatoblastoma: Clinical Cancer Research, 23 (13) e115-e122.
Sumazin P, Chen Y, Treviño LR, Sarabia SF, Hampton OA, Patel P, Mistretta T-A, Zorman B, Thompson P, Heczey A, Comerford S, Wheeler DA, Chintagumpala M, Meyers R, Rakheja D, Finegold MJ, Tomlinson G, Parsons DW, and López-Terrada D. 2017 Integrated Genomic Analysis of Hepatoblastoma Identifies Distinct Molecular and Prognostic Subgroups, Hepatology, 65: 104-121
Comerford SA, HinnantEA, ChenY, BansalH, KlapprothS, RakhejaD, Lopez-TerradaD, O’DonnellKA, FinegoldMJ, ParsonsDW, TomlinsonGE, Hammer RE. Hepatoblastoma modeling in mice places nrf2 within a cancer field established by mutant b-catenin. J. Clin Invest.Insight, 2016 1(16)e88549.
Mette LA, PulidoSaldivar AM, Poullard NE, Torres IC, Seth SG, Pollock BH, Tomlinson GE. Reaching High-Risk Underserved Individuals for Cancer Genetic Counseling by Videoteleconferencing. J Comm Supp Onc,14(4):162-8.