The major focus of our research effort concerns the mechanisms of
obesity-induced metabolic diseases such as type 2 diabetes, which is a
serious disease that affects 8.3% of the population in the United
States. Currently we are using molecular biology, biochemical, and cell
biology approaches as well as tissue-specific transgenic and knockout
mouse models to identify and characterize key molecules involved in the
regulation of glucose metabolism and energy homeostasis. Particularly we
are interested in how obesity leads to adipocyte dysregulation and how
adipose tissue dysfunction affects whole body energy homeostasis. It is
our hope that better understanding of the mechanisms underlying the
crosstalk between adipose tissues and other tissues will generate
important information for the development of new therapeutic drugs for
the treatment of obesity-associated disorders such as Type 2 diabetes,
cancer, and aging.
Ryu J, Galan AK, Xin X, Dong
F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo
S, Musi N, DeFronzo RA, Deng C, White M.F, Liu F, and Dong LQ. APPL1
potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the
insulin receptor. Cell Report. 2014, In press.
Liu M, Bai J, He S, Villarreal R, Hu D, Zhang CT, Yang X, Liang H,
Slaga T, Yu H, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F. Grb10 promotes lipolysis and thermogenesis
by phosphorylation-dependent feedback inhibition of mTORC1. Cell Metabolism. 2014, In press.
Zhang J, Zhang N, Liu M, Li X, Zhou L, Huang W, Xu Z, Liu J, Musi N, DeFronzo RA, Cunningham JM, Zhou Z, Lu XY, Liu F. Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis. Diabetes. 2012 Dec;61(12):3189-98.
Liu M, Xiang R, Wilk SA, Zhang N, Sloane LB, Azarnoush K, Zhou L, Chen
H, Xiang G, Walter CA, Austad SN, Musi N, DeFronzo RA, Asmis R, Scherer
PE, Dong LQ, Liu F. Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes. 2012 Nov;61(11):2776-86.
Kikani CK, Verona EV, Ryu J, Shen Y, Ye Q, Zheng L, Qian Z, Sakaue H, Nakamura K, Du J, Ji Q, Ogawa W, Sun LZ, Dong LQ, Liu F. Proliferative and antiapoptotic signaling stimulated by nuclear-localized PDK1 results in oncogenesis. Sci Signal. 2012 Nov 6;5(249):ra80.