The Kokovay lab studies mechanisms that regulate adult
neurogenesis and neural stem cell quiescence, activation, migration and
differentiation. Neural stem cells are tightly regulated by the surrounding
microenvironment. The major focus of the lab is to understand how different
cellular compartments within the microenvironment influence neural stem cells
under normal homeostasis and in the context of injury and aging.
vasculature is a known regulator of neural stem cells and we are studying how
secreted molecules from endothelial cells regulate proliferation and migration
of neural stem cells. We are also interested in the role immune cells play in
regulating neural stem cell function and dysfunction seen during aging.
Apple DM, Kokovay E. Vascular niche contribution to age-associated neural stem cell dysfunction. Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H896-H902. doi: 10.1152/ajpheart.00154.2017. Epub 2017 Aug 11. Review. PMID: 28801522
Apple DM, Solano-Fonseca R, Kokovay E.Neurogenesis in the aging brain.Biochem Pharmacol. 2017 Oct 1;141:77-85. doi: 10.1016/j.bcp.2017.06.116. Epub 2017 Jun 16. Review. PMID: 28625813
Solano Fonseca R, Mahesula S, Apple DM, Raghunathan R, Dugan A, Cardona A, O'Connor J, Kokovay E. Neurogenic Niche Microglia Undergo Positional Remodeling and Progressive Activation Contributing to Age-Associated Reductions in Neurogenesis.
Stem Cells Dev. 2016 Apr 1;25(7):542-55. doi: 10.1089/scd.2015.0319. Epub 2016 Mar 16. PMID: 26857912
Apple DM, Fonseca RS, Kokovay E. The role of adult neurogenesis in psychiatric and cognitive disorders.Brain Res. 2017 Jan 15;1655:270-276. doi: 10.1016/j.brainres.2016.01.023. Epub 2016 Jan 19. Review.
PMID: 26801829Kokovay E,
Wang Y, Kusek G, Wurster R, Lederman P, Lowry N, Shen Q, Temple S. VCAM1 Is Essentialto Maintain the Structure of the SVZ Niche and Acts as an Environmental Sensorto Regulate SVZ Lineage Progression. Cell
Stem Cell. 2012 Aug 3;11(2):220-30.
Goderie S, Wang Y, Lotz S, Lin G, Sun Y, Roysam B, Shen Q, Temple S. Adult SVZ lineagecells home to and leave the vascular niche via differential responses toSDF1/CXCR4 signaling. Cell Stem Cell. 2010 Aug
Fasano CA, Phoenix TN, Kokovay E,
Lowry N, Elkabetz Y, Dimos JT, Lemischka IR, Studer L, Temple S. Bmi-1 cooperateswith Foxg1 to maintain neural stem cell self-renewal in the forebrain.
Genes Dev. 2009 Mar 1;23(5):561-74.
Shen Q, Temple S. The incredibleelastic brain: how neural stem cells expand our minds.
Neuron. 2008 Nov 6;60(3):420-9.
Shen Q, Wang Y, Kokovay E, Lin
G, Chuang SM, Goderie SK, Roysam B, Temple S. Adult SVZ stem cellslie in a vascular niche: a quantitative analysis of niche cell-cellinteractions. Cell Stem Cell. 2008 Sep