Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

Dmitri Ivanov, Ph.D.

P0160 photo ivanovdmitri

RESEARCH

Dr. Dmitri Ivanov's lab looks at how physical interactions at protein interfaces determine biological outcomes. Inhibition of protein-protein interactions remains one of the major challenges and opportunities of modern molecular pharmacology. 

One of the goals of our studies is to identify critical contacts on protein interfaces that could potentially be blocked for therapeutic purposes. We are particularly interested in the assembly of higher-order macromolecular structures such as viral shells or multi-subunit cellular machines. We have developed novel drug-discovery strategies that combine NMR spectroscopy, computational methods and chemical biology tools.


Selected Publications

Yang Y, Brandariz-Nuñez A, Fricke T, Ivanov DN, Sarnak Z, Diaz-Griffero F. Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction. Virology. 2014 Jan 5;448:217-28.

Brandariz-Nuñez A, Valle-Casuso JC, White TE, Nguyen L, Bhattacharya A, Wang Z, Demeler B, Amie S, Knowlton C, Kim B, Ivanov DN, Diaz-Griffero F. Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1. Retrovirology. 2013 Nov 12;10:131.

Biris N, Tomashevski A, Bhattacharya A, Diaz-Griffero F, Ivanov DN. Rhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral core. J Mol Biol. 2013 Dec 13;425(24):5032-44.

Brandariz-Nuñez A, Roa A, Valle-Casuso JC, Biris N, Ivanov D, Diaz-Griffero F. Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α. Virology. 2013 Jan 20;435(2):463-71.

Biris N, Yang Y, Taylor AB, Tomashevski A, Guo M, Hart PJ, Diaz-Griffero F, Ivanov DN. Structure of the rhesus monkey TRIM5α PRYSPRY domain, the HIV capsid recognition module.Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13278-83.

Assistant Professor
Biochemistry and Structural Biology

Education

Ph.D., Structural Biology and Biophysics, Brandeis University, 2001

B.S., Biophysics, St. Petersburg State University, 1994

B.S., Physics, Northeastern University, 1993

Contact

Email: IVANOV@UTHSCSA.EDU

Phone: (210) 567-8781

Research Profile
More Info...

Graduate Students

Frank Herkules