Please note: The University of Texas Health Science Center at San Antonio will now be called "UT Health San Antonio."

Search Program Faculty/Research

David S. Weiss, Ph.D.

Weiss david lab


y-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. Dysfunctions of GABA-mediated inhibition have been implicated in the etiology of a variety of brain disorders such as epilepsy. Furthermore, GABA receptors are a target for a variety of therapeutic, neuroactive compounds such as benzodiazepines and barbiturates.

Selected Publications

Khatri A, Weiss DS. The role of Loop F in the activation of the GABA receptor.J Physiol. 2010 Jan 1;588(Pt 1):59-66.

Li P, Khatri A, Bracamontes J, Weiss DS, Steinbach JH, Akk G. Site-specific fluorescence reveals distinct structural changes induced in the human rho 1 GABA receptor by inhibitory neurosteroids.Mol Pharmacol. 2010 Apr;77(4):539-46.

Khatri A, Sedelnikova A, Weiss DS.Sructural Rearrangements in Loop F of the GABA Receptor Signal LIgand Binding, Not Channel Activation. Biophys J. 2009 Jan:96(1):45-55.

Zheleznova NN, Sedelnikova A, Weiss DS.Function and modulation of delta-containing GABA(A) receptors.Psychoneuroendocrinology. 2009 Sep 17.

Wotring VE, Weiss, DS. Charge scan reveals an extended region at the intracellular end of the GABA receptor pore that can influence ion selectivity. J Gen Physiol. 2008 Jan;131(1):87-97.

Dean, GSBS
Professor, Department of Cellular and Integrative Physiology


B.A., University of North Carolina at Chapel Hill, 1980

Ph.D., Baylor College of Medicine, 1987



Phone: (210) 567-3713

Research Profile
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