David S. Weiss, Ph.D.
y-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in
the mammalian brain. Dysfunctions of GABA-mediated inhibition have been
implicated in the etiology of a variety of brain disorders such as
epilepsy. Furthermore, GABA receptors are a target for a variety of
therapeutic, neuroactive compounds such as benzodiazepines and
Khatri A, Weiss DS. The role of Loop F in the activation of the GABA receptor.J Physiol. 2010 Jan 1;588(Pt 1):59-66.
Li P, Khatri A, Bracamontes J, Weiss DS, Steinbach JH, Akk G. Site-specific
fluorescence reveals distinct structural changes induced in the human
rho 1 GABA receptor by inhibitory neurosteroids.Mol Pharmacol. 2010 Apr;77(4):539-46.
Khatri A, Sedelnikova A, Weiss DS.Sructural Rearrangements in Loop F of the GABA Receptor Signal LIgand Binding, Not Channel Activation. Biophys J. 2009 Jan:96(1):45-55.
Zheleznova NN, Sedelnikova A, Weiss DS.Function and modulation of delta-containing GABA(A) receptors.Psychoneuroendocrinology. 2009 Sep 17.
Wotring VE, Weiss, DS. Charge scan reveals an extended region at the intracellular end of the GABA receptor pore that can influence ion selectivity. J Gen Physiol. 2008 Jan;131(1):87-97.
Professor, Department of Cellular and Integrative Physiology
B.A., University of North Carolina at Chapel Hill, 1980
Ph.D., Baylor College of Medicine, 1987
Phone: (210) 567-3713