Dr. David Kadosh's laboratory studies the major human fungal pathogen Candida albicans.
Although present as a commensal in the digestive tract of most healthy people, C. albicans is also capable of causing a wide variety of systemic and mucosal infections in immunocompromised individuals. Research in our laboratory focuses on a specific virulence property of C. albicans, the ability to undergo a reversible morphological transition from yeast to filaments. We are specifically interested in determining: 1) the mechanisms that specify C. albicans morphology and control induction of the filamentous growth program in response to host inducing signals, 2) the mechanisms by which individual genes in the C. albicans filamentous growth program function to promote the establishment and maintenance of infection in host tissues.
Vipulanandan, G., Herrera, M., Wiederhold, N.P., Li, X., Mintz, J., Wickes, B.L., Kadosh, D. Dynamics of Mixed- Candida Species Biofilms in Response to Antifungals. J. Dent. Res. doi: 10.1177/0022034517729351 (2017) (Epub ahead of print).
Kadosh, D., Najvar, L.K., Bocanegra, R., Olivo, M., Kirkpatrick, W.R., Wiederhold, N.P., Patterson, T.F. Effect of antifungal treatment in a diet-based murine model of disseminated candidiasis acquired via the gastrointestinal tract. Antimicrob. Agents Chemother. 60(11): 6703-6708 (2016).
Childers, D.S., Kadosh, D. Filament condition-specific response elements control the expression of NRG1 and UME6, key transcriptional regulators of morphology and virulence in Candida albicans. PLoS One 2015 Mar;10(3):e0122775.
Albataineh, M.T., Lazzell, A., Lopez-Ribot, J.L., Kadosh, D. Ppg1, a PP2A-type protein phosphatase, controls filament extension and virulence in Candida albicans. Eukaryot. Cell 2014 Dec;13(12):1538-1547.
Childers, D.S., Mundodi, V., Banerjee, M., Kadosh, D. A 5’ UTR-mediated translational efficiency mechanism inhibits the Candida albicans morphological transition. Mol. Microbiol. 2014 May;92(3):570-585.
Lackey E, Vipulanandan G, Childers DS, Kadosh D. Comparative evolution of morphological regulatory functions in Candida species. Eukaryot Cell. 2013 Oct;12(10):1356-68.
Carlisle PL, Kadosh D. A genome-wide transcriptional analysis of morphology determination in Candida albicans. Mol Biol Cell. 2013 Feb;24(3):246-60.