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Search Program Faculty/Research

Daniel J. Lodge, Ph.D.

Lodge photo


The mesolimbic dopamine system regulates cognitive, motivational and behavioral processes critical to normal functioning. Dysfunction in this system has been linked to a number of psychiatric disorders including schizophrenia. Our research is focused on trying to better understand the regulation of the dopamine system in both normal and disease states. Using a combination of techniques including, in vivo electrophysiology, molecular biology and behavior we are attempting to develop novel treatments for schizophrenia. This includes pharmacological, neurosurgical and cell based methods. We strongly believe that a better understanding of the pathophysiology associated with neuropsychiatric disease is essential for the development of novel therapeutic approaches.

Selected Publications

Chen L, Perez SM, Lodge DJ. An augmented dopamine system function is present prior to puberty in the MAM rodent model of schizophrenia. Developmental Neurobiology. 2014 - In Press.

Perez SM, Lodge DJ. Hippocampal interneuron transplants reverse aberrant dopamine system function and behavior in a rodent model of schizophrenia. Mol Psychiatry. 2013 Nov;18(11):1193-8.

Shah A, Lodge DJ. A loss of hippocampal perineuronal nets produces deficits in dopamine system function: relevance to the positive symptoms of schizophrenia. Transl Psychiatry. 2013 Jan 15;3:e215.

Perez SM, Shah A, Asher A, Lodge DJ. Hippocampal deep brain stimulation reverses physiological and behavioural deficits in a rodent model of schizophrenia. Int J Neuropsychopharmacol. 2013 Jul;16(6):1331-9

Lodge DJ, Grace AA. Hippocampal dysregulation of dopamine system function and the pathophysiology of schizophrenia. Trends Pharmacol Sci. 2011 Sep;32(9):507-13.

Associate Professor



Ph.D., Medicine, Monash University, 2003

B.S., Pharmacology, Monash University, 1998



Phone: 210-567-4188

Research Profile
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