Failure to maintain genetic stability can result in a variety of
biological outcomes potentially including aging, cancer, birth defects
and reproductive failure. Dr. Christi Walter's research approach is multidisciplinary
involving stem cell biology, reproductive biology, aging, cancer,
genetics, and cell and molecular biology to address the role of DNA
repair and mutagenesis in sustaining normal biological functions.
Dong Q, Wang D, Bandyopadhyay A, Gao H, Gorena KM, Hildreth K, Rebel VI, Walter CA, Huang C, Sun LZ. Mammospheres from murine mammary stem cell-enriched basal cells: clonal characteristics and repopulating potential. Stem Cell Res. 2013 May;10(3):396-404.
Murphey P, McLean DJ, McMahan CA, Walter CA, McCarrey JR. Enhanced genetic integrity in mouse germ cells. Biol Reprod. 2013 Jan 3;88(1):6.
Herzig MC, Hildreth K, Huamani J, Perez M, Goins BA, McMahan CA, Reddick RL, Walter CA. Human
O6 -methylguanine-DNA methyltransferase containing C145A does not
prevent hepatocellular carcinoma in C3HeB/FeJ transgenic mice. Mol Carcinog. 2013 Apr;52(4):275-85.
Mu X, Lin S, Yang J, Chen C, Chen Y, Herzig MC, Washburn K, Halff GA, Walter CA, Sun B, Sun LZ. TGF-β
signaling is often attenuated during hepatotumorigenesis, but is
retained for the malignancy of hepatocellular carcinoma cells. PLoS One. 2013 May 21;8(5):e63436.
Zhou T, Hasty P, Walter CA, Bishop AJ, Scott LM, Rebel VI. Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA? Exp Hematol. 2013 Aug;41(8):665-74.